rs10492367

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body height

Yengo L et al. “A saturated map of common genetic variants associated with human height.” Nature 610(7933):704-712 (2022)
Allele T
OR 0.02
p 9.0e-88
N 5,314,291
Large GWAS
European, Hispanic or Latin American, East Asian, African unspecified, South Asian

osteoarthritis, hip

Tachmazidou I et al. “Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.” Nature Genetics 51(2):230-236 (2019)
Allele T
OR 1.16
p 1.0e-24
N 393,873
Major Consortium StudyLarge GWAS
European
Henkel C et al. “Genome-wide association meta-analysis of knee and hip osteoarthritis uncovers genetic differences between patients treated with joint replacement and patients without joint replacement.” Annals of the Rheumatic Diseases 82(3):384-392 (2023)
Allele T
OR 1.13
p 1.0e-21
N 646,831
Meta-analysisLarge GWAS
European
Styrkarsdottir U et al. “Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis.” Nature Genetics 50(12):1681-1687 (2018)
Allele T
OR 1.14
p 7.0e-19
N 613,790
Meta-analysisLarge GWAS
European

osteoarthritis, hip, osteoarthritis, knee

Tachmazidou I et al. “Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.” Nature Genetics 51(2):230-236 (2019)
Allele T
OR 1.06
p 2.0e-8
N 417,596
Major Consortium StudyLarge GWAS
European
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Research that mentions this SNP (2)

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Identification of Novel Loci Associated With Hip Shape: A Meta-Analysis of Genomewide Association Studies
Meta-analysisN=15,934Baird DA et al.(2019)· Journal of Bone and Mineral Research

A GWAS meta-analysis of 15,934 individuals identified 9 SNPs across 8 loci associated with hip shape phenotypes derived from DXA scans. Five SNPs were associated with hip shape mode 1 (HSM1) at genome-wide significance (p < 5×10⁻⁹), three with HSM2, and one with HSM5. Most loci were close to genes involved in endochondral bone formation (SOX9, PTHLH, FGFR4, NKX3-2, DICER1, RUNX1, HHIP) and also associated with height. Three SNPs showed associations with hip osteoarthritis and one with hip fracture risk.

Traits studied:Femoral neck bone mineral densityHeightHip fractureHip osteoarthritisHip shapeWaist circumference
PubMedDOIMetascience Observatory
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Genome‐Wide Association Study of Radiographic Knee Osteoarthritis in North American Caucasians
AssociationN=7,066Yau MS et al.(2017)· Arthritis &amp; Rheumatology

This genome-wide association study (GWAS) of radiographic tibiofemoral knee osteoarthritis in 3,898 cases and 3,168 controls from four North American cohorts identified one novel locus near LSP1P3 (rs4867568, OR=0.84, P=3.02×10⁻⁶) and confirmed associations with previously reported loci GDF5 (rs143383, OR=1.12, P=2.13×10⁻³) and FTO (rs8044769, OR=1.10, P=6.13×10⁻³). Despite the large sample size and standardized radiographic phenotyping, no variants achieved genome-wide significance, highlighting the polygenic nature of knee OA.

Traits studied:Knee osteoarthritisRadiographic tibiofemoral osteoarthritis
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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