rs10497813

This is a intron variant variant in the PLCL1 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

rheumatoid arthritis, anti-citrullinated protein antibody seropositivity, rheumatoid factor seropositivity measurement

Ishigaki K et al. “Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis.” Nature Genetics 54(11):1640-1651 (2022)

Allele T

OR 1.08

p 2.0e-10

N 267,597

Large GWAS

multi-ancestry

allergic disease

Hinds DA et al. “A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.” Nature Genetics 45(8):907-11 (2013)

Allele G

OR 0.07

p 6.0e-10

N 53,862

Meta-analysisLarge GWAS

European

rheumatoid arthritis

Ishigaki K et al. “Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis.” Nature Genetics 54(11):1640-1651 (2022)

Allele T

OR 1.06

p 8.0e-9

N 276,020

Large GWAS

multi-ancestry

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Research that mentions this SNP (1)

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A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks

Meta-analysisN=4,915Manav Kapoor et al.(2013)· Human Genetics

A meta-analysis of two genome-wide association studies (COGA and SAGE) identifying genetic variants associated with maximum number of alcoholic drinks consumed in 24 hours (maxdrinks). The study combined 4,915 participants of European descent and found suggestive associations with multiple loci including rs1229984 (ADH1B, p=2.04×10⁻⁸), rs4758317 (LMO1, p=7.2×10⁻⁷), and variants in PLCL1 (p=4.07×10⁻⁶). Approximately 40% of the variance in maxdrinks was explained by genome-wide SNPs.

Traits studied:Alcohol dependenceExcessive alcohol consumptionMaximum number of alcoholic drinks in 24-hour period

PubMed DOI Metascience Observatory

About PLCL1

Predicted to enable GABA receptor binding activity and phosphatidylinositol-4,5-bisphosphate phospholipase C activity. Predicted to be involved in several processes, including gamma-aminobutyric acid signaling pathway; negative regulation of cold-induced thermogenesis; and phosphatidylinositol-mediated signaling. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]