rs10512597
This is a intron variant variant in the CD300LF gene.
▶GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
C-reactive protein measurement
Ligthart S et al. “Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.” American Journal of Human Genetics 103(5):691-706 (2018)
Allele T
OR 0.04
p 4.0e-14
N 206,158
Large GWAS
European
circulating fibrinogen levels
Danik JS et al. “Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.” Circulation. Cardiovascular Genetics 2(2):134-41 (2009)
Allele A
OR 6.45
p 8.0e-11
N 17,686
Large GWAS
European
Sabater-Lleal M et al. “Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.” Circulation 128(12):1310-24 (2013)
Allele A
OR 0.01
p 1.0e-8
N 91,323
Meta-analysisLarge GWAS
multi-ancestry
Red cell distribution width
Chen MH et al. “Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.” Cell 182(5):1198-1213.e14 (2020)
Allele T
OR —
p 6.0e-10
N 563,352
Large GWAS
multi-ancestry
protein measurement
Hartley AE et al. “Deciphering tissue-specific protein regulation for insights into cardiometabolic disease.” Molecular Metabolism 104:102314 (2026)
Allele C
OR —
p 5.0e-8
N 262
Small GWAS
European
About CD300LF
This gene encodes a member of the CD300 protein family. Members of this family are cell surface glycoproteins with a single IgV-like extracellular domain, and are involved in the regulation of immune response. The encoded protein is an inhibitory receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
View all CD300LF variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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