rs1055129

This is a coding sequence variant variant in the TRIM47 gene.

▶

GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

drug use measurement, Hypercholesterolemia

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele A

OR 0.04

p 1.0e-12

N 404,034

Major Consortium StudyLarge GWAS

multi-ancestry

brain attribute

Fornage M. et al. “Genome‐wide association studies of cerebral white matter lesion burden” Annals of Neurology (2011)

Allele G

OR —

p 3.0e-11

N 9,361

Large GWAS

European

▶

Research that mentions this SNP (1)

▶

Genome‐wide association studies of cerebral white matter lesion burden

Meta-analysisN=12,385Fornage M. et al.(2011)· Annals of Neurology

Genome-wide meta-analysis of 9,361 Europeans identified six genome-wide significant SNPs on chromosome 17q25 associated with white matter hyperintensity (WMH) burden. The most significant SNP, rs3744028 (P = 4.0×10⁻⁹ discovery, P = 1.3×10⁻⁷ replication, P = 4.0×10⁻¹⁵ combined), and rs1055129 were replicated in 3,024 additional individuals. Risk alleles increased WMH burden by 4-8% of mean burden.

Traits studied:Cerebral white matter lesionsWhite matter hyperintensities (WMH) burden

PubMed DOI Metascience Observatory

About TRIM47

Enables ubiquitin protein ligase activity. Involved in protein ubiquitination. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]