rs10734252

This is a coding sequence variant variant.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

systolic blood pressure

Giri A et al. “Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.” Nature Genetics 51(1):51-62 (2019)

Allele A

OR 0.30

p 4.0e-17

N 459,777

Large GWAS

multi-ancestry

systolic blood pressure, alcohol drinking

Feitosa MF et al. “Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.” Plos One 13(6):e0198166 (2018)

Allele A

OR —

p 5.0e-15

N 133,355

Large GWAS

multi-ancestry

type 2 diabetes mellitus

Flannick J et al. “Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.” Nature 570(7759):71-76 (2019)

Allele G

OR 1.11

p 4.0e-10

N 35,912

Large GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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