rs10749918

This variant is located in the POGLUT3 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

prostate carcinoma

Wang A et al. “Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants.” Nature Genetics 55(12):2065-2074 (2023)

Allele G

OR 1.04

p 3.0e-14

N 944,762

Large GWAS

multi-ancestry

clonal hematopoiesis

Stacey SN et al. “Genetics and epidemiology of mutational barcode-defined clonal hematopoiesis.” Nature Genetics 55(12):2149-2159 (2023)

Allele G

OR 1.10

p 2.0e-13

N 59,219

Large GWAS

European

uterine fibroid

Kim J et al. “Genome-wide meta-analysis identifies novel risk loci for uterine fibroids within and across multiple ancestry groups.” Nature Communications 16(1):2273 (2025)

Allele C

OR 0.05

p 5.0e-9

N 253,542

Meta-analysisLarge GWAS

East Asian, Central Asian, South Asian

About POGLUT3

Enables UDP-glucosyltransferase activity and UDP-xylosyltransferase activity. Involved in protein O-linked glycosylation via serine. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endomembrane system. [provided by Alliance of Genome Resources, Jul 2025]