rs10759426

This is a intron variant variant in the SVEP1 gene.

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

systolic blood pressure

Keaton JM et al. “Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.” Nature Genetics 56(5):778-791 (2024)

Allele C

OR 0.34

p 2.0e-21

N 1,028,980

Large GWAS

multi-ancestry

platelet count

Chen MH et al. “Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.” Cell 182(5):1198-1213.e14 (2020)

Allele C

OR 0.02

p 4.0e-15

N 542,827

Large GWAS

European

diastolic blood pressure

Allele C

OR 0.17

p 2.0e-13

N 1,028,980

Large GWAS

multi-ancestry

pulse pressure measurement

Allele C

OR 0.18

p 2.0e-12

N 1,028,980

Large GWAS

multi-ancestry

About SVEP1

Enables integrin binding activity. Involved in negative regulation of vasoconstriction and positive regulation of platelet activation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

View all SVEP1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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