rs10770612

This variant is located in the LINC02398 gene.

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GWAS Catalog Trait Associations (6)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

pulse pressure measurement

Keaton JM et al. “Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.” Nature Genetics 56(5):778-791 (2024)

Allele G

OR 0.32

p 1.0e-48

N 1,028,980

Large GWAS

multi-ancestry

Plotnikov D et al. “High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study.” Investigative Ophthalmology & Visual Science 63(6):29 (2022)

Allele G

OR 0.30

p 4.0e-22

N 526,001

Large GWAS

European

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele G

OR 0.02

p 7.0e-25

N 506,308

Large GWAS

multi-ancestry

Giri A et al. “Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.” Nature Genetics 51(1):51-62 (2019)

Allele G

OR 0.25

p 2.0e-15

N 459,777

Large GWAS

multi-ancestry

Yang ML et al. “Sex-specific genetic architecture of blood pressure.” Nature Medicine 30(3):818-828 (2024)

Allele G

OR 0.03

p 3.0e-25

N 349,328

Large GWAS

multi-ancestry

Warren HR et al. “Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.” Nature Genetics 49(3):403-415 (2017)

Allele G

OR 0.31

p 7.0e-15

N 140,886

Large GWAS

European

aortic stenosis

Kany S et al. “Multitrait analyses identify genetic variants associated with aortic valve function and aortic stenosis risk.” Nature Genetics 58(1):47-56 (2026)

Allele A

OR 0.03

p 3.0e-22

N 205,483

Large GWAS

European

systolic blood pressure

Allele G

OR 0.26

p 7.0e-18

N 1,028,980

Large GWAS

multi-ancestry

Koskeridis F et al. “Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.” Nature Communications 15(1):9827 (2024)

Allele G

OR 0.01

p 7.0e-12

N 1,212,859

Large GWAS

European

aortic stenosis, aortic valve calcification

Thériault S et al. “Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation.” Nature Communications 15(1):2407 (2024)

Allele A

OR —

p 7.0e-13

N 956,682

Large GWAS

European

bulb of aorta size

Ramachandran S. Vasan et al. “Genetic Variants Associated With Cardiac Structure and Function” Jama (2009)

Allele G

OR 0.03

p 2.0e-8

N 12,612

Large GWAS

European

cardiovascular measurement

Kany S et al. “Multitrait analyses identify genetic variants associated with aortic valve function and aortic stenosis risk.” Nature Genetics 58(1):47-56 (2026)

Allele A

OR 0.05

p 1.0e-19

N 96,385

Large GWAS

European

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Research that mentions this SNP (1)

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Genetic Variants Associated With Cardiac Structure and Function

Meta-analysisN=16,706Ramachandran S. Vasan et al.(2009)· JAMA

Meta-analysis of genome-wide association studies in 12,612 individuals from the EchoGen consortium identified 16 genetic loci associated with echocardiographic traits in stage 1, with 5 loci replicating in stage 2: rs89107 and rs11153768 (6q22) associated with left ventricular diastolic dimensions (explaining <1% variance), and rs17470137, rs4026608, rs10770612, rs893817 (5q23, 12q14, 12p12, 15q24 loci) associated with aortic root size (explaining 1-3% variance).

Traits studied:Aortic root sizeLeft atrial sizeLeft ventricular diastolic internal dimensionsLeft ventricular massLeft ventricular systolic dysfunctionLeft ventricular wall thickness

PubMed DOI Metascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

rs10770612

GWAS Catalog Trait Associations (6)

pulse pressure measurement

aortic stenosis

systolic blood pressure

aortic stenosis, aortic valve calcification

bulb of aorta size

cardiovascular measurement

Research that mentions this SNP (1)

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