rs10774671

This is a intron variant variant in the OAS1 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

COVID-19

“Mapping the human genetic architecture of COVID-19.” Nature 600(7889):472-477 (2021)
Allele A
OR 1.20
p 4.0e-13
N 1,489,959
Large GWAS
multi-ancestry

body height

Yengo L et al. “A saturated map of common genetic variants associated with human height.” Nature 610(7933):704-712 (2022)
Allele G
OR 0.00
p 3.0e-11
N 5,314,291
Large GWAS
European, Hispanic or Latin American, East Asian, African unspecified, South Asian

respiratory failure, COVID-19

Degenhardt F et al. “Detailed stratified GWAS analysis for severe COVID-19 in four European populations.” Human Molecular Genetics 31(23):3945-3966 (2022)
Allele G
OR 0.90
p 1.0e-10
N 2,641,520
Large GWAS
European, NR
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ClinVar annotation

Likely Benign★★★☆
8 submitters8 publications

OAS1-related disorder; not specified

View on ClinVar →
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Research that mentions this SNP (2)

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Identification of a new susceptibility variant for multiple sclerosis in OAS1 by population genetics analysis
AssociationN=1,163Rachele Cagliani et al.(2012)· Human Genetics

The authors identified rs11352835 (A/- insertion/deletion in OAS1 exon 7) as a novel multiple sclerosis susceptibility variant through population genetics analysis in 660 MS cases and 503 controls (OR 1.27, p = 0.010, allelic model). While the previously reported splice-site variant rs10774671 shows neutral evolution, the downstream exon 7 region exhibits signatures of balancing selection, and tight linkage between the two SNPs may explain conflicting results across populations.

Traits studied:Multiple Sclerosis
PubMedDOIMetascience Observatory
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2′‐5′ oligoadenylate synthetase 1 polymorphism is associated with prostate cancer
AssociationN=304Sanjay Mandal et al.(2011)· Cancer

This case-control study of 304 samples (164 cancer, 140 control) found that the OAS1 rs2660 AA genotype was significantly associated with increased prostate cancer risk (OR=2.4, p=0.0006), while the GG genotype was protective (OR=0.066, p<0.0001), reducing risk by 92%. The association was consistent across both Caucasian and African American populations, with the AA genotype showing additive effects with age.

Traits studied:Prostate cancer
PubMedDOIMetascience Observatory

About OAS1

This interferon-induced gene encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein plays a key role in innate cellular antiviral response, and has been implicated in other cellular processes like cell growth and apoptosis. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral infection, including SARS-CoV-2, and diabetes mellitus, type 1. This gene is located in a cluster of related genes on chromosome 12. [provided by RefSeq, May 2022]

View all OAS1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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