OAS1

2'-5'-oligoadenylate synthetase 1

Summary

This interferon-induced gene encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein plays a key role in innate cellular antiviral response, and has been implicated in other cellular processes like cell growth and apoptosis. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral infection, including SARS-CoV-2, and diabetes mellitus, type 1. This gene is located in a cluster of related genes on chromosome 12. [provided by RefSeq, May 2022]

Known Variants256 total

rsidPosition (GRCh37)AllelesClassClinVar
rs11188984212:113,344,628G/A—benign
rs74622640612:113,344,845A/G—uncertain significance
rs77248047812:113,344,849T/C—uncertain significance
rs127026247212:113,344,852A/G—uncertain significance
rs254093918412:113,344,856C/G—likely benign
rs76461326912:113,344,862T/C—likely benign
rs77672164612:113,344,866C/G—uncertain significance
rs127004285012:113,344,871C/T—likely benign
rs254093933312:113,344,876C/A—uncertain significance
rs37354669012:113,344,897A/G—benign
rs37702760912:113,344,902C/T—likely benign
rs204330505212:113,344,904C/G—likely benign
rs254093960912:113,344,907G/A—likely benign
rs37028427612:113,344,909C/T—uncertain significance
rs204330556612:113,344,922C/T—likely benign
rs11783596112:113,344,923C/T—likely benign
rs77746703712:113,344,924G/A—uncertain significance
rs254093984112:113,344,930A/G—likely benign
rs37148815012:113,344,940T/C—likely benign
rs76918212712:113,344,946T/C—likely benign
rs77054012812:113,344,960G/T—conflicting classifications of pathogenicity
rs76195192912:113,344,965C/G—uncertain significance
rs76320540412:113,344,978G/A—uncertain significance
rs20025974512:113,344,983C/T—likely benign
rs75135052412:113,344,984G/A—benign
rs75487201112:113,344,987G/A—uncertain significance
rs91944485612:113,344,990G/T—benign
rs76746053612:113,344,997C/T—likely benign
rs13892127812:113,345,007G/A—conflicting classifications of pathogenicity
rs204330926712:113,345,018G/A—likely benign
rs6109617012:113,345,090A/G—benign
rs795688012:113,345,167A/C—benign
rs224019012:113,346,127C/A—benign
rs20064236512:113,346,329C/T—benign
rs37393769912:113,346,330G/A—likely benign
rs254094497312:113,346,331T/A—uncertain significance
rs130399719912:113,346,346C/T—likely benign
rs53966472812:113,346,347T/C—uncertain significance
rs75254102212:113,346,348C/T—uncertain significance
rs75312013712:113,346,355C/T—uncertain significance
rs254094508112:113,346,359G/A—uncertain significance
rs14284724112:113,346,366C/T—conflicting classifications of pathogenicity
rs76411082112:113,346,367C/A—likely benign
rs37431329012:113,346,370C/A—likely benign
rs77852997012:113,346,373A/T—uncertain significance
rs55767018512:113,346,374G/A—likely benign
rs14743153112:113,346,377C/T—uncertain significance
rs126329633212:113,346,378G/A—uncertain significance
rs78134959012:113,346,379A/G—likely benign
rs14849994412:113,346,384A/C—likely benign
rs14280954412:113,346,385C/T—likely benign
rs76084286512:113,346,386G/A—uncertain significance
rs155522311812:113,346,387C/T—uncertain significance
rs254094530612:113,346,391C/A—benign
rs138003583512:113,346,394G/A—likely benign
rs213629536612:113,346,419A/G—uncertain significance
rs129206046312:113,346,424T/A—uncertain significance
rs15063685112:113,346,431C/G—benign
rs77509812512:113,346,440C/T—likely benign
rs76398355312:113,346,444G/A—uncertain significance
rs124813789712:113,346,447G/A—uncertain significance
rs75383741512:113,346,455A/G—uncertain significance
rs136640910912:113,346,465T/C—uncertain significance
rs117757000812:113,346,466T/C—likely benign
rs13980486812:113,346,470A/G—likely benign
rs76467201712:113,346,471G/A—uncertain significance
rs74995833012:113,346,475G/C—likely benign
rs155522315412:113,346,486G/A—uncertain significance
rs125760265112:113,346,493A/G—likely benign
rs130995554712:113,346,494G/A—uncertain significance
rs37710021312:113,346,500G/A—benign
rs254094618412:113,346,507C/T—likely benign
rs37678062412:113,346,508C/T—likely benign
rs20012755812:113,346,509G/A—likely benign
rs74975347512:113,346,516T/A—uncertain significance
rs213629593912:113,346,522T/G—pathogenic
rs74598217712:113,346,533C/T—uncertain significance
rs77215883312:113,346,534G/A—uncertain significance
rs14685951312:113,346,546C/A—uncertain significance
rs77642642412:113,346,548C/T—uncertain significance
rs102134009512:113,346,549G/A—uncertain significance
rs76167388412:113,346,552C/T—uncertain significance
rs14763914512:113,346,553G/A—likely benign
rs254094664812:113,346,561T/C—uncertain significance
rs128410481212:113,346,562C/T—likely benign
rs11190221512:113,346,563G/A—uncertain significance
rs14447678312:113,346,574G/A—likely benign
rs14231417712:113,346,575C/T—conflicting classifications of pathogenicity
rs75428377512:113,346,577C/G—likely benign
rs75778908612:113,346,583C/T—likely benign
rs77961186012:113,346,584G/C—conflicting classifications of pathogenicity
rs20075341412:113,346,588A/G—benign
rs20030729312:113,346,589G/A—likely benign
rs74719348712:113,346,590G/C—uncertain significance
rs147894013112:113,346,592G/A—likely benign
rs147145318512:113,346,597A/T—uncertain significance
rs98342535512:113,346,603A/G—uncertain significance
rs213629657612:113,346,604T/A—uncertain significance
rs254094717912:113,346,607G/A—likely benign
rs94390989812:113,346,615C/A—uncertain significance

Showing 100 of 256 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.