rs10830962

This variant is located in the LOC124902733 gene.

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

blood glucose amount

Gu Y et al. “Genetic architecture and risk prediction of gestational diabetes mellitus in Chinese pregnancies.” Nature Communications 16(1):4178 (2025)

Allele C

OR 0.16

p 1.0e-56

N 56,912

Large GWAS

East Asian

Kim YJ et al. “Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.” Nature Genetics 43(10):990-5 (2011)

Allele C

OR 0.04

p 1.0e-16

N 12,545

Large GWAS

East Asian

metabolic syndrome

Kristiansson K et al. “Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.” Circulation. Cardiovascular Genetics 5(2):242-9 (2012)

Allele G

OR 0.12

p 5.0e-16

N 10,564

Large GWAS

European

gestational diabetes

Kwak SH et al. “A genome-wide association study of gestational diabetes mellitus in Korean women.” Diabetes 61(2):531-41 (2012)

Allele G

OR 1.45

p 2.0e-13

N 1,710

Large GWAS

East Asian

type 2 diabetes mellitus

Go MJ et al. “New susceptibility loci in MYL2, C12orf51 and OAS1 associated with 1-h plasma glucose as predisposing risk factors for type 2 diabetes in the Korean population.” Journal of Human Genetics 58(6):362-5 (2013)

Allele C

OR 0.04

p 5.0e-13

N 7,696

Large GWAS

East Asian

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Research that mentions this SNP (2)

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MTNR1B gene on susceptibility to gestational diabetes mellitus: a two-stage hospital-based study in Southern China

AssociationN=1,429Yulong Jia et al.(2020)· Molecular Genetics and Genomics

Two-stage case-control study of 1,429 pregnant women in Southern China examining MTNR1B gene variants and gestational diabetes mellitus (GDM) susceptibility. SNP rs10830963 was significantly associated with increased GDM risk in the combined analysis (additive model OR=1.36, 95%CI=1.17-1.59, P<0.001; dominant model OR=1.45, 95%CI=1.15-1.83, P=0.005). The rs10830963 variant showed interaction with maternal age and BMI in contributing to GDM risk.

Traits studied:Gestational diabetes mellitus (GDM)

PubMed DOI Metascience Observatory

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COX2 and NOS3 gene polymorphisms in women with gestational diabetes

ReviewMaciej Tarnowski et al.(2017)· The Journal of Gene Medicine

This comprehensive review synthesizes literature on gestational diabetes mellitus (GDM), demonstrating its complex multifactorial etiology involving genetic factors (SNPs in GCKR, KCNQ1, MTNR1B, TCF7L2), epigenetic modifications (DNA methylation and microRNA expression), and alterations in microbial composition across multiple body sites. While certain SNP variants are associated with GDM phenotypes globally, genetic predisposition alone does not explain disease development; lifestyle factors can modify epigenetic signatures and microbiota composition to modulate risk. Evidence indicates genes, epigenetic alterations, and microbiota can transfer from mother to offspring with long-term health consequences.

Traits studied:Cardiovascular diseaseFetal macrosomiaGestational diabetes mellitusHyperglycemiaHyperlipidemiaHypoglycemiaImpaired insulin secretionInflammatory conditionsInsulin resistanceMetabolic syndromeObesityPreeclampsiaType 2 diabetes

PubMed DOI Metascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

rs10830962

GWAS Catalog Trait Associations (4)

blood glucose amount

metabolic syndrome

gestational diabetes

type 2 diabetes mellitus

Research that mentions this SNP (2)

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