rs10838524
This is a regulatory region variant variant in the CRY2 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
glucose measurement
▶Research that mentions this SNP (1)
▶Association of Tef polymorphism with depression in Parkinson diseaseAssociationN=408Ping Hua et al.(2012)· Movement Disorders
This study examined the association between circadian gene polymorphisms and depression severity in 408 Parkinson's disease patients. The Tef rs738499 polymorphism was significantly associated with higher Hamilton Depression Rating Scale (HAMD) scores (P = 0.004), explaining 1.8% of variance in depression symptoms after adjusting for clinical variables. Cry1 rs2287161 and Cry2 rs10838524 showed no significant associations with depression in this PD cohort.
About CRY2
This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
View all CRY2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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