CRY2
cryptochrome circadian regulator 2
Summary
This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
Known Variants38 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs754319957 | 11:45,869,000 | T/C | — | uncertain significance |
| rs3747548 | 11:45,869,013 | C/A | — | benign |
| rs1417104105 | 11:45,869,052 | C/G | — | uncertain significance |
| rs776050157 | 11:45,869,082 | C/T | — | uncertain significance |
| rs2086160724 | 11:45,869,101 | C/G | — | uncertain significance |
| rs2086161954 | 11:45,869,202 | A/G | — | uncertain significance |
| rs10838524 | 11:45,870,177 | A/G | regulatory region variant | — |
| rs11605924 | 11:45,873,091 | A/C | intron variant | — |
| rs11038689 | 11:45,874,264 | A/G | intron variant | — |
| rs2292912 | 11:45,877,688 | C/G | regulatory region variant | — |
| rs1401417 | 11:45,880,110 | C/G | regulatory region variant | — |
| rs892055644 | 11:45,880,339 | C/T | — | uncertain significance |
| rs145426016 | 11:45,880,390 | A/G | — | uncertain significance |
| rs201922005 | 11:45,880,391 | C/T | — | uncertain significance |
| rs2086263691 | 11:45,880,412 | A/G | — | uncertain significance |
| rs375307775 | 11:45,882,442 | C/T | — | uncertain significance |
| rs372798103 | 11:45,882,529 | G/A | — | uncertain significance |
| rs2494768340 | 11:45,883,628 | C/A | — | uncertain significance |
| rs2494768500 | 11:45,883,691 | G/A | — | uncertain significance |
| rs778118557 | 11:45,889,179 | A/G | — | uncertain significance |
| rs779078142 | 11:45,889,200 | C/T | — | uncertain significance |
| rs35488012 | 11:45,889,228 | C/T | — | benign |
| rs200303700 | 11:45,889,277 | T/C | — | uncertain significance |
| rs564636387 | 11:45,889,280 | C/T | — | uncertain significance |
| rs2494780748 | 11:45,891,129 | G/A | — | uncertain significance |
| rs1218286651 | 11:45,891,169 | C/T | — | uncertain significance |
| rs751909436 | 11:45,891,208 | C/T | — | uncertain significance |
| rs569804127 | 11:45,891,226 | A/G | — | uncertain significance |
| rs2494781235 | 11:45,891,300 | G/C | — | uncertain significance |
| rs7123390 | 11:45,891,418 | G/A | intron variant | — |
| rs372919618 | 11:45,891,993 | C/T | — | uncertain significance |
| rs374547914 | 11:45,892,002 | G/A | — | uncertain significance |
| rs139936457 | 11:45,892,014 | G/C | — | uncertain significance |
| rs367724794 | 11:45,892,075 | G/A | — | uncertain significance |
| rs2494784506 | 11:45,892,401 | G/A | — | uncertain significance |
| rs141568119 | 11:45,893,711 | G/C | — | uncertain significance |
| rs10838527 | 11:45,903,194 | A/G | upstream gene variant | — |
| rs2292910 | 11:45,903,613 | A/C | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.