rs11605924

This is a intron variant variant in the CRY2 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

blood glucose amount

Lagou V et al. “Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.” Nature Communications 12(1):24 (2021)
Allele A
OR 0.02
p 1.0e-26
N 140,595
Large GWAS
European
Manning AK et al. “A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.” Nature Genetics 44(6):659-69 (2012)
Allele A
OR 0.02
p 3.0e-13
N 58,074
Large GWAS
European
Dupuis J et al. “New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.” Nature Genetics 42(2):105-116 (2010)
Allele A
OR 0.01
p 1.0e-14
N 46,186
Large GWAS
European
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Research that mentions this SNP (4)

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A Diabetes-Associated Genetic Variant is Associated with Diastolic Dysfunction and Cardiovascular Disease
AssociationN=15,215John Molvin et al.(2020)· ESC Heart Failure

This association study examined 43 diabetes-related SNPs in relation to diastolic dysfunction and cardiovascular disease across two Swedish cohorts. HNF1B rs757210 (T-allele) was the main finding, associated with prevalent diastolic dysfunction in both the discovery cohort (MPP-RES; OR 1.21, P=0.024) and replication cohort (VARA; OR 1.38, P=0.042), and with increased risk of incident CVD (HR 1.05, P=0.042) but not CHF over 30+ years of follow-up.

Traits studied:Cardiovascular diseaseCongestive heart failureDiastolic dysfunctionType 2 diabetes
PubMedDOIMetascience Observatory
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Transethnic insight into the genetics of glycaemic traits: fine-mapping results from the Population Architecture using Genomics and Epidemiology (PAGE) consortium
AssociationN=26,760Stephanie A. Bien et al.(2017)· Diabetologia

Transethnic fine-mapping study of glycaemic traits in 26,760 participants (Hispanic/Latino, African, Asian, and Native American) using the Metabochip. Replicated 31/39 fasting glucose and 14/17 fasting insulin loci from European GWAS. Identified two novel secondary signals at G6PC2-rs477224 and GCK-rs2908290, a population-specific signal at G6PC2-rs77719485 in African ancestry, and one novel locus at SLC17A2-rs75862513 for fasting insulin.

Traits studied:Fasting glucoseFasting insulinType 2 diabetes
PubMedDOIMetascience Observatory
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Excess maternal transmission of variants in the THADA gene to offspring with type 2 diabetes
AssociationN=5,674Rashmi B. Prasad et al.(2016)· Diabetologia

Family-based study examining parent-of-origin effects (POE) on type 2 diabetes risk in 4,211 individuals from Botnia and 1,463 from the Hungarian Transdanubian Biobank. Three loci showed nominal POE, with the strongest signal at rs7578597 in THADA showing excess maternal transmission of the risk T allele to diabetic offspring (Botnia pPOE=0.01, HTB pPOE=0.045, combined pPOE=0.0006). Five CpG sites flanking rs7578597 showed differential methylation between diabetic and non-diabetic islets, supporting potential THADA imprinting. Meta-analysis confirmed association with type 2 diabetes (OR=1.24, 95% CI 1.12-1.36, p=1.96×10⁻⁵).

Traits studied:BMIBlood pressureGlucose toleranceHyperglycaemiaImpaired fasting glucose (IFG)Impaired glucose tolerance (IGT)Insulin secretionInsulin sensitivityLipidsType 2 diabetesWaist-to-hip circumference ratio
PubMedDOIMetascience Observatory
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Season-dependent associations of circadian rhythm-regulating loci (CRY1, CRY2 and MTNR1B) and glucose homeostasis: the GLACIER Study
AssociationN=16,499Frida Renström et al.(2015)· Diabetologia

A prospective cohort study of 16,499 Swedish participants from the GLACIER study examined season-dependent associations between circadian rhythm-regulating SNPs (CRY1 rs8192440, CRY2 rs11605924, MTNR1B rs10830963) and glucose homeostasis. The CRY1 A-allele was associated with lower fasting glucose only during the light season (β=-0.04 mmol/l, p=0.02), while CRY2 and MTNR1B variants showed associations with 2h glucose only during the dark season. Results suggest biologically plausible season-dependent effects on glucose metabolism related to extreme seasonal daylight variation at high latitude.

Traits studied:2-hour glucose (OGTT)Fasting glucoseGlucose homeostasis
PubMedDOIMetascience Observatory

About CRY2

This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

View all CRY2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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