rs2292910

This is a upstream gene variant variant in the CRY2 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

sex hormone-binding globulin measurement

Ruth KS et al. “Using human genetics to understand the disease impacts of testosterone in men and women.” Nature Medicine 26(2):252-258 (2020)
Allele A
OR 0.01
p 1.0e-11
N 368,929
Large GWAS
European
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Research that mentions this SNP (1)

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Association of osteoporosis with genetic variants of circadian genes in Chinese geriatrics
AssociationN=597Li Y. et al.(2016)· Osteoporosis International

This cross-sectional candidate gene study examined 14 tag SNPs in 7 circadian genes for association with osteoporosis risk in 597 Chinese geriatric subjects. CRY2 rs2292910 showed protective effects (AC genotype OR=0.647, p=0.044), while MTNR1B rs3781638 showed increased risk (GG genotype OR=2.058, p=0.044). The findings suggest circadian gene variants may influence bone mineral density and osteoporosis susceptibility.

Traits studied:Bone mineral densityOsteopeniaOsteoporosis
PubMedDOIMetascience Observatory

About CRY2

This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

View all CRY2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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