rs10847697

This is a synonymous variant in the SLC15A4 gene — it does not change the protein's amino acid sequence.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

systemic lupus erythematosus

Zhang YM et al. “Shared genetic study gives insights into the shared and distinct pathogenic immunity components of IgA nephropathy and SLE.” Molecular Genetics and Genomics : Mgg 296(4):1017-1026 (2021)

Allele A

OR —

p 5.0e-8

N 4,049

Large GWAS

East Asian

About SLC15A4

Enables several functions, including L-histidine transmembrane transporter activity; peptide:proton symporter activity; and peptidoglycan transmembrane transporter activity. Involved in dipeptide import across plasma membrane; peptidoglycan transport; and positive regulation of pattern recognition receptor signaling pathway. Located in endolysosome membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all SLC15A4 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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