rs10883890

This variant is located in the SH3PXD2A gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

total blood protein measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele C
OR 0.01
p 4.0e-8
N 448,242
Large GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Genetic predictors of risk and resilience in psychiatric disorders: A cross‐disorder genome‐wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia
AssociationN=2,246Lauren M. McGrath et al.(2013)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

A genome-wide association study of 2,246 psychiatric patients across three disorders (MDD, bipolar disorder, schizophrenia) identified variants in ADAMTS16 showing the strongest association with physical health-related quality of life (rs16875288, p = 5.87 × 10⁻⁸, approaching but not exceeding genome-wide significance). The findings demonstrate that genetic variation in functional impairment operates as a distinct axis independent from symptom severity, with psychiatric symptoms accounting for less than one-third of the variance in functional outcomes.

Traits studied:Bipolar DisorderEmployment statusFunctional impairmentHealth-related quality of lifeMajor Depressive DisorderMental health componentPhysical health componentSchizophrenia
PubMedDOIMetascience Observatory

About SH3PXD2A

Predicted to enable superoxide-generating NADPH oxidase activator activity. Involved in osteoclast fusion and superoxide metabolic process. Located in cytosol and podosome. [provided by Alliance of Genome Resources, Jul 2025]

View all SH3PXD2A variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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