rs10885997

This is a synonymous variant in the PNLIPRP2 gene — it does not change the protein's amino acid sequence.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

level of phosphatidylcholine

Harshfield EL et al. “Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci.” Bmc Medicine 19(1):232 (2021)

Allele G

OR 0.11

p 2.0e-13

N 13,814

Large GWAS

European

low density lipoprotein cholesterol measurement

Liu DJ et al. “Exome-wide association study of plasma lipids in >300,000 individuals.” Nature Genetics 49(12):1758-1766 (2017)

Allele G

OR 0.01

p 7.0e-9

N 297,824

Large GWAS

multi-ancestry

About PNLIPRP2

This gene encodes a lipase that hydrolyzes galactolipids, the main components of plant membrane lipids. An allelic polymorphism in this gene results in both coding and non-coding variants; the reference genome represents the non-coding allele. [provided by RefSeq, Aug 2015]

View all PNLIPRP2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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