rs10887800

This case-control study in 286 Iranian subjects (60 hypertensive, 71 with CAD+hypertension, 61 with CAD, 69 controls) investigated the association between renalase rs10887800 polymorphism and cardiovascular disease risk, and examined how atorvastatin, losartan, and captopril therapy affect renalase activity. Higher renalase activity was observed in hypertensive patients (136.18±15.63) versus CAD patients (76.15±16.78; P<0.001), but renalase rs10887800 showed no significant association with hypertension or CAD risk in either recessive or dominant genetic models (P>0.05). Atorvastatin and losartan therapy increased renalase activity in hypertensive patients with AG/GG genotypes but had no effect in CAD+hypertension patients.

This two-stage case-control study investigated the renalase gene (C10orf59) as a susceptibility gene for essential hypertension in 2,586 northern Han Chinese subjects. Two SNPs showed significant associations: rs2576178 (OR=1.58, 95% CI 1.25-2.00, P=0.0002) and rs2296545 (OR=1.61, 95% CI 1.26-2.04, P=0.0002), with the latter encoding the Asp37Glu amino acid change. Risk-associated haplotypes further confirmed the gene's association with hypertension.