RNLS

renalase, FAD dependent amine oxidase

Summary

Enables several functions, including NADH binding activity; epinephrine binding activity; and monoamine oxidase activity. Involved in negative regulation of blood pressure and negative regulation of heart rate. Located in extracellular region. Implicated in essential hypertension and hypertension. Biomarker of end stage renal disease. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants80 total

rsidPosition (GRCh37)AllelesClassClinVar
rs1050954010:90,023,033T/Cregulatory region variant—
rs7814703310:90,034,448C/T—benign
rs11634194810:90,034,487C/T—likely benign
rs1074956810:90,034,488G/A—benign
rs7281807010:90,034,545A/T—benign
rs7281807110:90,034,883C/T—benign
rs4558583810:90,034,899C/T—benign
rs76338502210:90,045,127A/G—uncertain significance
rs54498508410:90,045,136A/G—uncertain significance
rs75649974810:90,045,201T/A—likely benign
rs74588967310:90,045,220T/A—uncertain significance
rs7414668910:90,045,483A/T—benign
rs7414669010:90,045,512G/A—benign
rs1120270410:90,054,899T/Cintron variant—
rs224151510:90,073,986G/A—benign
rs1120270910:90,074,005A/G—benign
rs1120271010:90,074,140G/A—benign
rs1120271110:90,074,145A/G—benign
rs53111750510:90,074,294G/A—likely benign
rs77497441210:90,074,353G/A—uncertain significance
rs77010531410:90,074,357C/T—uncertain significance
rs14930046610:90,074,381G/A—uncertain significance
rs11423196410:90,074,401G/A—benign
rs18386710110:90,074,407T/C—benign
rs1088780010:90,075,843A/Gintron variantassociation
rs5633753210:90,100,003T/Cintron variant—
rs253923522410:90,122,312T/C—uncertain significance
rs11744649410:90,122,314T/C—likely benign
rs74644173510:90,122,318G/A—uncertain significance
rs18863936810:90,122,332A/G—uncertain significance
rs76785440910:90,122,340G/A—likely benign
rs75109300010:90,122,345G/A—uncertain significance
rs75751962310:90,122,351A/G—uncertain significance
rs15124542010:90,122,360T/C—uncertain significance
rs11637626310:90,122,388A/T—benign
rs74772461910:90,122,398G/A—uncertain significance
rs55671683110:90,122,431C/T—uncertain significance
rs7852546010:90,122,468G/T—benign
rs374027910:90,122,512C/T—benign
rs7282001310:90,122,676T/C—benign
rs1120273610:90,142,203A/Tintron variant—
rs790773210:90,182,764T/G——
rs18859160510:90,198,855T/Cintron variant—
rs459698110:90,205,199A/Cintron variant—
rs461906010:90,205,339C/Aintron variant—
rs1073635410:90,206,538T/Cintron variant—
rs1088782310:90,210,183A/Gintron variant—
rs7576536110:90,212,985T/Cintron variant—
rs257617010:90,258,744T/Cintron variant—
rs72568310:90,258,876C/Tintron variant—
rs247795410:90,264,140T/Cintron variant—
rs257615910:90,296,467A/Tintron variant—
rs7821697310:90,332,611A/G—benign
rs74809794210:90,332,662G/A—uncertain significance
rs75817720410:90,332,782A/T—uncertain significance
rs13929458810:90,332,784C/T—likely benign
rs4131702410:90,332,928G/T—likely benign
rs132590510:90,333,045T/A—benign
rs1120277910:90,341,049G/A—benign
rs1088783610:90,341,051G/A—benign
rs14015892810:90,341,359A/G—likely benign
rs14982548510:90,341,385G/C—uncertain significance
rs76533540010:90,341,407C/A—uncertain significance
rs14351386210:90,341,438C/T—conflicting classifications of pathogenicity
rs74721453410:90,341,452A/G—uncertain significance
rs7282009510:90,341,844T/C—benign
rs14758868910:90,341,960G/A—uncertain significance
rs19996056010:90,341,968T/A—uncertain significance
rs76764282910:90,341,974G/A—uncertain significance
rs144383200210:90,341,987T/G—uncertain significance
rs14200365110:90,342,024C/T—benign
rs124273929410:90,342,055A/G—uncertain significance
rs7841295510:90,342,240A/G—likely benign
rs7445514310:90,342,286T/A—likely benign
rs229654510:90,342,837C/Gmissense variantassociation
rs185075449710:90,342,893G/C—uncertain significance
rs95363268810:90,342,916A/C—uncertain significance
rs55756487410:90,343,118G/A—likely benign
rs14982283610:90,343,252T/A—likely benign
rs257617810:90,343,398A/Gupstream gene variantbenign

Gene information from NCBI Gene. Variant classifications from ClinVar.