rs2296545

This is a variant in the RNLS gene that changes a glutamate to an aspartate.

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ClinVar annotation

Association★★★☆
4 submitters2 publications

Stage 5 chronic kidney disease

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Research that mentions this SNP (1)

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Renalase gene is a novel susceptibility gene for essential hypertension: a two-stage association study in northern Han Chinese population
AssociationN=2,586Qi Zhao et al.(2007)· Journal of Molecular Medicine

This two-stage case-control study investigated the renalase gene (C10orf59) as a susceptibility gene for essential hypertension in 2,586 northern Han Chinese subjects. Two SNPs showed significant associations: rs2576178 (OR=1.58, 95% CI 1.25-2.00, P=0.0002) and rs2296545 (OR=1.61, 95% CI 1.26-2.04, P=0.0002), with the latter encoding the Asp37Glu amino acid change. Risk-associated haplotypes further confirmed the gene's association with hypertension.

Traits studied:Essential hypertension
PubMedDOIMetascience Observatory

About RNLS

Enables several functions, including NADH binding activity; epinephrine binding activity; and monoamine oxidase activity. Involved in negative regulation of blood pressure and negative regulation of heart rate. Located in extracellular region. Implicated in essential hypertension and hypertension. Biomarker of end stage renal disease. [provided by Alliance of Genome Resources, Jul 2025]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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