rs10887914

This is a regulatory region variant variant in the TSPAN14 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

systolic blood pressure

Keaton JM et al. “Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.” Nature Genetics 56(5):778-791 (2024)

Allele C

OR 0.19

p 2.0e-15

N 1,028,980

Large GWAS

multi-ancestry

pulse pressure measurement

Allele C

OR 0.13

p 5.0e-15

N 1,028,980

Large GWAS

multi-ancestry

Evangelou E et al. “Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.” Nature Genetics 50(10):1412-1425 (2018)

Allele C

OR 0.13

p 1.0e-14

N 757,601

Large GWAS

European

About TSPAN14

Enables enzyme binding activity. Involved in positive regulation of Notch signaling pathway; protein localization to plasma membrane; and protein maturation. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all TSPAN14 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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