rs10903323
This is a intron variant variant in the MSRA gene.
▶Research that mentions this SNP (1)
▶Identification of the oxidative stress–related gene MSRA as a rheumatoid arthritis susceptibility locus by genome‐wide pathway analysisAssociationN=4,316Jose‐Ezequiel Martín et al.(2010)· Arthritis & Rheumatism
This genome-wide pathway analysis study identified MSRA (rs10903323) as a novel rheumatoid arthritis susceptibility locus through pathway prioritization of previous GWAS data. In a combined analysis of 1,818 RA patients and 2,498 controls, rs10903323 was associated with RA (P = 3.19 × 10⁻⁴, OR 1.28), while rs12029840 near HIPK1 showed stronger replication (P = 1.64 × 10⁻⁸, OR 1.55). The findings implicate oxidative stress and the MSRA-mediated apoptosis pathway in RA pathogenesis.
About MSRA
This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
View all MSRA variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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