MSRA
methionine sulfoxide reductase A
Summary
This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Known Variants66 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs73189192 | 8:9,910,639 | C/G | coding sequence variant | — |
| rs1369282579 | 8:9,912,030 | C/G | — | uncertain significance |
| rs770734947 | 8:9,912,042 | C/T | — | uncertain significance |
| rs148811380 | 8:9,912,049 | C/T | — | uncertain significance |
| rs1585050285 | 8:9,912,057 | C/T | — | uncertain significance |
| rs891281233 | 8:9,912,066 | C/T | — | uncertain significance |
| rs138517353 | 8:9,912,092 | G/C | — | uncertain significance |
| rs755928429 | 8:9,912,144 | C/G | — | uncertain significance |
| rs778639208 | 8:9,912,153 | C/G | — | uncertain significance |
| rs759188048 | 8:9,924,288 | G/A | — | — |
| rs4840463 | 8:9,958,321 | A/C | intron variant | — |
| rs17689007 | 8:9,974,824 | G/A | intron variant | — |
| rs7843924 | 8:9,976,540 | C/T | intron variant | — |
| rs13256357 | 8:9,979,535 | C/G | — | — |
| rs1484642 | 8:9,986,655 | G/C | intron variant | — |
| rs77620296 | 8:10,008,789 | A/T | — | — |
| rs7017212 | 8:10,022,938 | G/T | intron variant | — |
| rs7823314 | 8:10,030,255 | G/A | intron variant | — |
| rs756707975 | 8:10,065,351 | C/G | — | uncertain significance |
| rs775294870 | 8:10,065,384 | C/T | — | uncertain significance |
| rs1156932960 | 8:10,065,403 | C/A | — | uncertain significance |
| rs17749155 | 8:10,068,073 | G/C | — | — |
| rs11775334 | 8:10,071,620 | A/T | — | — |
| rs6999631 | 8:10,086,411 | G/T | — | — |
| rs34919878 | 8:10,099,504 | G/A | intron variant | — |
| rs1342129348 | 8:10,102,643 | A/C | — | uncertain significance |
| rs2486286204 | 8:10,102,677 | A/C | — | uncertain significance |
| rs1171413366 | 8:10,102,678 | A/G | — | uncertain significance |
| rs184219307 | 8:10,102,682 | G/A | — | likely benign |
| rs2486286516 | 8:10,102,701 | C/G | — | uncertain significance |
| rs2952186 | 8:10,124,081 | C/T | intron variant | — |
| rs560182665 | 8:10,144,677 | C/T | — | — |
| rs56220175 | 8:10,147,256 | C/T | intron variant | — |
| rs10903323 | 8:10,149,567 | A/G | intron variant | — |
| rs6601427 | 8:10,156,025 | T/C | intron variant | — |
| rs183626962 | 8:10,159,071 | G/A | — | uncertain significance |
| rs2486575056 | 8:10,159,084 | G/C | — | uncertain significance |
| rs367978405 | 8:10,159,135 | C/G | — | uncertain significance |
| rs371090925 | 8:10,159,136 | G/C | — | uncertain significance |
| rs79001489 | 8:10,161,088 | C/A | intron variant | — |
| rs28611339 | 8:10,170,037 | G/T | intron variant | — |
| rs144066044 | 8:10,177,398 | C/T | — | uncertain significance |
| rs778510160 | 8:10,177,452 | G/A | — | uncertain significance |
| rs4509385 | 8:10,180,196 | A/T | — | — |
| rs34762419 | 8:10,180,595 | A/G | intron variant | — |
| rs7816657 | 8:10,214,421 | T/A | — | — |
| rs9650650 | 8:10,247,976 | C/T | intron variant | — |
| rs4610752 | 8:10,248,962 | A/T | — | — |
| rs17709397 | 8:10,249,861 | G/A | regulatory region variant | — |
| rs7831971 | 8:10,250,399 | G/T | — | — |
| rs13264580 | 8:10,250,699 | C/T | intron variant | — |
| rs2001337 | 8:10,251,154 | G/A | intron variant | — |
| rs7460436 | 8:10,254,322 | C/T | intron variant | — |
| rs13254263 | 8:10,255,181 | A/C | — | — |
| rs73197281 | 8:10,263,282 | T/C | — | — |
| rs3750310 | 8:10,283,426 | G/A | intron variant | — |
| rs139382033 | 8:10,285,672 | C/T | — | likely benign |
| rs199649360 | 8:10,285,689 | C/G | — | uncertain significance |
| rs200629688 | 8:10,285,694 | G/A | — | uncertain significance |
| rs374677955 | 8:10,285,703 | G/A | — | benign |
| rs558902117 | 8:10,285,752 | G/T | — | uncertain significance |
| rs761898137 | 8:10,285,764 | A/G | — | uncertain significance |
| rs543375336 | 8:10,285,775 | G/A | — | uncertain significance |
| rs753476880 | 8:10,285,785 | G/A | — | uncertain significance |
| rs199964551 | 8:10,285,790 | G/A | — | likely benign |
| rs774636640 | 8:10,285,809 | G/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.