rs4610752
This variant is located in the MSRA gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
left ventricular ejection fraction measurement
Forrest IS et al. “Genetic and phenotypic profiling of supranormal ejection fraction reveals decreased survival and underdiagnosed heart failure.” European Journal of Heart Failure 24(11):2118-2127 (2022)
Allele A
OR 0.14
p 2.0e-8
N 30,557
Large GWAS
African unspecified, Hispanic or Latin American, European, Asian unspecified, NR
About MSRA
This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
View all MSRA variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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