rs10911021
This variant is located in the LOC105371642 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
cardiovascular disease
▶Research that mentions this SNP (1)
▶Association Between a Genetic Variant Related to Glutamic Acid Metabolism and Coronary Heart Disease in Individuals With Type 2 DiabetesAssociationN=6,562Lu Qi et al.(2013)· JAMA
This genome-wide association study identified rs10911021 on chromosome 1q25 as significantly associated with coronary heart disease (CHD) risk specifically in type 2 diabetic patients (OR=1.36, 95% CI 1.22-1.51, P=2×10⁻⁸), but not in non-diabetic participants (OR=0.99, P=0.89). The risk allele homozygotes showed a 32% decrease in GLUL gene expression in endothelial cells and altered glutamic acid metabolism, suggesting a mechanistic link through the γ-glutamyl cycle.
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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