rs11031006

This is a intergenic variant variant in the ARL14EP-DT gene.

▶

GWAS Catalog Trait Associations (11)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

level of follitropin subunit beta in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.13
p 1.0e-85
N 47,745
Large GWAS
European

menstrual cycle attribute

Laisk T et al. “Large-scale meta-analysis highlights the hypothalamic-pituitary-gonadal axis in the genetic regulation of menstrual cycle length.” Human Molecular Genetics 27(24):4323-4332 (2018)
Allele A
OR 0.16
p 4.0e-36
N 44,871
Meta-analysisLarge GWAS
European

follicle stimulating hormone measurement

Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)
Allele A
OR 0.17
p 7.0e-31
N 10,708
Large GWAS
European
Venkatesh SS et al. “Genome-wide analyses identify 25 infertility loci and relationships with reproductive traits across the allele frequency spectrum.” Nature Genetics 57(5):1107-1118 (2025)
Allele A
OR 0.21
p 4.0e-15
N 6,095
Large GWAS
European

uterine fibroid

Kim J et al. “Genome-wide meta-analysis identifies novel risk loci for uterine fibroids within and across multiple ancestry groups.” Nature Communications 16(1):2273 (2025)
Allele A
OR 0.09
p 1.0e-21
N 709,132
Meta-analysisLarge GWAS
multi-ancestry
Gallagher CS et al. “Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis.” Nature Communications 10(1):4857 (2019)
Allele A
OR 1.10
p 6.0e-15
N 244,324
Large GWAS
European

age at first birth measurement, uterine fibroid

Xiao C et al. “Genetic contribution of reproductive traits to risk of uterine leiomyomata: a large-scale, genome-wide, cross-trait analysis.” American Journal of Obstetrics and Gynecology 230(4):438.e1-438.e15 (2024)
Allele A
OR —
p 9.0e-21
N 721,737
Large GWAS
European

Luteinizing hormone level

Venkatesh SS et al. “Genome-wide analyses identify 25 infertility loci and relationships with reproductive traits across the allele frequency spectrum.” Nature Genetics 57(5):1107-1118 (2025)
Allele A
OR 0.09
p 1.0e-18
N 41,650
Large GWAS
European
Hayes MG et al. “Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations.” Nature Communications 6:7502 (2015)
Allele A
OR 3.19
p 3.0e-16
N 645
Small GWAS
European

Uterine leiomyoma

Sliz E et al. “Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata.” Nature Communications 14(1):542 (2023)
Allele A
OR 0.92
p 1.0e-15
N 367,903
Large GWAS
European

Menorrhagia

Gallagher CS et al. “Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis.” Nature Communications 10(1):4857 (2019)
Allele G
OR 1.19
p 2.0e-13
N 220,759
Large GWAS
European

positive regulation of ovulation

Mbarek H et al. “Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility.” American Journal of Human Genetics 98(5):898-908 (2016)
Allele G
OR 1.14
p 1.0e-10
N 14,933
Large GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…