rs11031796
This is a intron variant variant in the WT1-AS gene.
▶GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
Inguinal hernia
Wei J et al. “Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank.” Hernia : the Journal of Hernias and Abdominal Wall Surgery 26(1):335-348 (2022)
Allele G
OR 1.11
p 1.0e-20
N 275,546
Major Consortium StudyLarge GWAS
European
Hiatus hernia
Ahmed WU et al. “Shared genetic architecture of hernias: A genome-wide association study with multivariable meta-analysis of multiple hernia phenotypes.” Plos One 17(12):e0272261 (2022)
Allele G
OR 1.07
p 4.0e-16
N 193,788
Meta-analysisLarge GWAS
European
pelvic organ prolapse
Pujol-Gualdo N et al. “Advancing our understanding of genetic risk factors and potential personalized strategies for pelvic organ prolapse.” Nature Communications 13(1):3584 (2022)
Allele A
OR 0.93
p 2.0e-15
N 574,377
Large GWAS
European
visceral adipose tissue quantity
Agrawal S et al. “Inherited basis of visceral, abdominal subcutaneous and gluteofemoral fat depots.” Nature Communications 13(1):3771 (2022)
Allele G
OR 0.05
p 5.0e-14
N 37,641
Large GWAS
European, East Asian, South Asian, African unspecified, NR
visceral:abdominal adipose tissue ratio measurement
Agrawal S et al. “Inherited basis of visceral, abdominal subcutaneous and gluteofemoral fat depots.” Nature Communications 13(1):3771 (2022)
Allele G
OR 0.06
p 6.0e-10
N 18,984
Large GWAS
European, East Asian, South Asian, African unspecified, NR
About WT1-AS
This gene is located upstream of the Wilms tumor 1 (WT1) gene; these two genes are bi-directionally transcribed from the same promoter region. This gene is imprinted in kidney, with preferential expression from the paternal allele. Imprinting defects at chromosome 11p13 may contribute to tumorigenesis. [provided by RefSeq, May 2014]
View all WT1-AS variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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