rs11057830
This is a intron variant variant in the SCARB1 gene.
▶GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
coronary artery disease
van der Harst P et al. “Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.” Circulation Research 122(3):433-443 (2018)
Allele A
OR 0.08
p 3.0e-20
N 250,736
Large GWAS
Nelson CP et al. “Association analyses based on false discovery rate implicate new loci for coronary artery disease.” Nature Genetics 49(9):1385-1391 (2017)
Allele A
OR 1.07
p 4.0e-9
N 63,731
Large GWAS
European, NR
heart failure
Jordà P et al. “Genetic analyses across cardiovascular traits: leveraging genetic correlations to empower locus discovery and prediction in common cardiovascular diseases.” Npj Genomic Medicine 10(1):65 (2025)
Allele A
OR 6.46
p 1.0e-10
N 358,418
Large GWAS
European
lipoprotein-associated phospholipase A(2) measurement
Yeo A et al. “Pharmacogenetic meta-analysis of baseline risk factors, pharmacodynamic, efficacy and tolerability endpoints from two large global cardiovascular outcomes trials for darapladib.” Plos One 12(7):e0182115 (2017)
Allele A
OR 3.67
p 7.0e-9
N 22,156
Meta-analysisLarge GWAS
multi-ancestry
Vitamin E level
Major JM et al. “Genome-wide association study identifies common variants associated with circulating vitamin E levels.” Human Molecular Genetics 20(19):3876-83 (2011)
Allele A
OR 0.03
p 8.0e-9
N 4,014
Large GWAS
multi-ancestry
HMG CoA reductase inhibitor use measurement
Wu Y et al. “Genome-wide association study of medication-use and associated disease in the UK Biobank.” Nature Communications 10(1):1891 (2019)
Allele A
OR 0.05
p 2.0e-8
N 290,385
Major Consortium StudyLarge GWAS
European
X-11308 measurement
Surendran P et al. “Rare and common genetic determinants of metabolic individuality and their effects on human health.” Nature Medicine 28(11):2321-2332 (2022)
Allele A
OR 0.08
p 2.0e-8
N 14,296
Large GWAS
European
About SCARB1
The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2 and facilitates cell entry by the virus, SARS-CoV2. [provided by RefSeq, Oct 2021]
View all SCARB1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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