rs11082011

This is a regulatory region variant variant in the CELF4 gene.

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GWAS Catalog Trait Associations (6)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

neuroticism measurement

Nagel M et al. “Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.” Nature Genetics 50(7):920-927 (2018)
Allele T
OR 9.95
p 3.0e-23
N 449,484
Meta-analysisLarge GWAS
European
Nagel M et al. “Item-level analyses reveal genetic heterogeneity in neuroticism.” Nature Communications 9(1):905 (2018)
Allele T
OR 9.42
p 4.0e-21
N 380,506
Large GWAS
European
Turley P et al. “Multi-trait analysis of genome-wide association summary statistics using MTAG.” Nature Genetics 50(2):229-237 (2018)
Allele T
OR 0.02
p 3.0e-12
N 168,105
Large GWAS
European
Wendt FR et al. “Sex-Specific Genetic and Transcriptomic Liability to Neuroticism.” Biological Psychiatry 93(3):243-252 (2023)
Allele T
OR 0.08
p 3.0e-10
N 145,669
Large GWAS
European

wellbeing measurement

Baselmans BML et al. “Multivariate genome-wide analyses of the well-being spectrum.” Nature Genetics 51(3):445-451 (2019)
Allele T
OR 0.01
p 7.0e-19
N 2,083,151
Large GWAS
European

mood instability measurement

Nagel M et al. “Item-level analyses reveal genetic heterogeneity in neuroticism.” Nature Communications 9(1):905 (2018)
Allele T
OR 6.83
p 9.0e-12
N 373,733
Large GWAS
European

grip strength measurement

Schoeler T et al. “Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline.” Nature Communications 16(1):4524 (2025)
Allele C
OR 0.01
p 2.0e-8
N 404,112
Large GWAS
European
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Research that mentions this SNP (1)

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Serotonin transporter polymorphism (5-HTTLPR) association with melancholic depression: a female specific effect?
AssociationN=1,394Bernhard T. Baune et al.(2008)· Depression and Anxiety

A study of 1,394 MDD patients examined whether polygenic scores for Big Five personality traits predict SSRI treatment response and remission. Polygenic scores for openness and neuroticism were significantly associated with SSRI treatment outcomes (p < 0.05), while conscientiousness was associated with response in the PGRN-AMPS sample. Cross-trait GWAS meta-analyses identified eight genetic loci shared between personality traits and SSRI treatment outcomes, with variants near YEATS4 associated with conscientiousness and SSRI response, and variants near PRAG1, MSRA, XKR6, ELAVL2, PLXNC1, PLEKHM1, and BRUNOL4 associated with neuroticism and SSRI remission.

Traits studied:AgreeablenessConscientiousnessExtraversionMajor depressive disorderNeuroticismOpennessPersonality traits (Big Five)SSRI treatment remissionSSRI treatment response
PubMedDOIMetascience Observatory

About CELF4

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

View all CELF4 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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