rs11088458
▶GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
heel bone mineral density
Morris JA et al. “An atlas of genetic influences on osteoporosis in humans and mice.” Nature Genetics 51(2):258-266 (2019)
Allele A
OR 0.04
p 4.0e-86
N 426,824
Large GWAS
European
Kemp JP et al. “Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis.” Nature Genetics 49(10):1468-1475 (2017)
Allele A
OR 0.04
p 4.0e-31
N 142,487
Large GWAS
European
bone fracture
Nethander M et al. “An atlas of genetic determinants of forearm fracture.” Nature Genetics 55(11):1820-1830 (2023)
Allele G
OR 1.06
p 2.0e-23
N 1,020,094
Large GWAS
European
Drugs affecting bone structure and mineralization use measurement
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele G
OR 0.09
p 3.0e-11
N 394,394
Large GWAS
multi-ancestry
hip fracture
Nethander M et al. “Assessment of the genetic and clinical determinants of hip fracture risk: Genome-wide association and Mendelian randomization study.” Cell Reports. Medicine 3(10):100776 (2022)
Allele G
OR 1.11
p 4.0e-10
N 735,354
Large GWAS
European
osteoporosis
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele G
OR 0.07
p 5.0e-10
N 667,227
Large GWAS
multi-ancestry
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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