Trait
SNPs associated with Osteoporosis
64 genetic variants across 19 genes have been associated with Osteoporosis in published research. Key genes include ALDH7A1, AXIN1, CCDC170.
Associated variants64 total
| rsid | Gene | Effect | Evidence |
|---|---|---|---|
| rs784288 | MECOM | GWAS association (p=4.0e-08) | Meta-analysis |
| rs731236 | VDR | Increased osteoporosis risk in Caucasians | Meta-analysis |
| rs1800012 | COL1A1 | Increased fracture and osteoporosis risk | Meta-analysis |
| rs9923231 | VKORC1 | Increased osteoporosis risk | Meta-analysis |
| rs1544410 | VDR | Altered osteoporosis risk, ancestry-dependent | Meta-analysis |
| rs9533090 | — | GWAS association (p=6.0e-23) | Major Consortium Study |
| rs4869741 | — | GWAS association (p=3.0e-20) | Major Consortium Study |
| rs4870044 | CCDC170 | GWAS association (p=5.0e-20) | Major Consortium Study |
| rs9533095 | — | GWAS association (p=1.0e-18) | Major Consortium Study |
| rs2062375 | COLEC10 | GWAS association (p=3.0e-11) | Major Consortium Study |
| rs917726 | FAM3C | GWAS association (p=1.0e-17) | Major Consortium Study |
| rs9272364 | HLA-DQA1 | GWAS association (p=3.0e-17) | Major Consortium Study |
| rs6679981 | — | GWAS association (p=3.0e-17) | Major Consortium Study |
| rs34434863 | — | GWAS association (p=5.0e-16) | Major Consortium Study |
| rs6960700 | SEM1 | GWAS association (p=3.0e-15) | Major Consortium Study |
| rs10085588 | SEM1 | GWAS association (p=2.0e-14) | Major Consortium Study |
| rs884205 | TNFRSF11A | GWAS association (p=3.0e-13) | Major Consortium Study |
| rs9998898 | — | GWAS association (p=8.0e-13) | Major Consortium Study |
| rs1524058 | — | GWAS association (p=1.0e-12) | Major Consortium Study |
| rs28569233 | — | GWAS association (p=4.0e-12) | Major Consortium Study |
| rs944082 | — | GWAS association (p=3.0e-11) | Major Consortium Study |
| rs2905982 | HROB | GWAS association (p=4.0e-11) | Major Consortium Study |
| rs28362709 | — | GWAS association (p=7.0e-13) | Major Consortium Study |
| rs4988321 | LRP5 | GWAS association (p=3.0e-15) | Major Consortium Study |
| rs56364616 | FAM3C | GWAS association (p=3.0e-18) | Major Consortium Study |
| rs7173595 | — | GWAS association (p=7.0e-13) | Major Consortium Study |
| rs8047501 | — | GWAS association (p=9.0e-12) | Major Consortium Study |
| rs87939 | — | GWAS association (p=1.0e-13) | Major Consortium Study |
| rs142005327 | — | GWAS association (p=1.0e-16) | Large GWAS |
| rs9594738 | — | GWAS association (p=4.0e-16) | Large GWAS |
| rs3779381 | — | GWAS association (p=5.0e-15) | Large GWAS |
| rs34102936 | — | GWAS association (p=2.0e-14) | Large GWAS |
| rs11228240 | — | GWAS association (p=2.0e-14) | Large GWAS |
| rs33983260 | — | GWAS association (p=7.0e-12) | Large GWAS |
| rs2566755 | WLS | GWAS association (p=8.0e-12) | Large GWAS |
| rs34240317 | — | GWAS association (p=9.0e-12) | Large GWAS |
| rs144680237 | — | GWAS association (p=2.0e-11) | Large GWAS |
| rs436448 | — | GWAS association (p=2.0e-11) | Large GWAS |
| rs3741619 | — | GWAS association (p=4.0e-11) | Large GWAS |
| rs11088458 | — | GWAS association (p=5.0e-10) | Large GWAS |
| rs56154705 | LRP5 | GWAS association (p=9.0e-10) | Large GWAS |
| rs2071805 | — | GWAS association (p=9.0e-10) | Large GWAS |
| rs9482772 | — | GWAS association (p=2.0e-09) | Large GWAS |
| rs880610 | — | GWAS association (p=2.0e-09) | Large GWAS |
| rs578031265 | STK39 | GWAS association (p=2.0e-09) | Large GWAS |
| rs4869744 | CCDC170 | GWAS association (p=4.0e-09) | Large GWAS |
| rs10204976 | — | GWAS association (p=8.0e-09) | Large GWAS |
| rs112725769 | — | GWAS association (p=8.0e-09) | Large GWAS |
| rs389264 | — | GWAS association (p=9.0e-09) | Large GWAS |
| rs34414754 | — | GWAS association (p=1.0e-08) | Large GWAS |
| rs397932743 | — | GWAS association (p=2.0e-08) | Large GWAS |
| rs2864700 | — | GWAS association (p=2.0e-08) | Large GWAS |
| rs10242100 | — | GWAS association (p=3.0e-08) | Large GWAS |
| rs115242848 | — | GWAS association (p=3.0e-08) | Large GWAS |
| rs9262558 | — | GWAS association (p=3.0e-08) | Large GWAS |
| rs10794639 | — | GWAS association (p=3.0e-08) | Large GWAS |
| rs494453 | RAP1A | GWAS association (p=4.0e-08) | Large GWAS |
| rs4448201 | — | GWAS association (p=4.0e-08) | Large GWAS |
| rs12408050 | — | GWAS association (p=4.0e-08) | Large GWAS |
| rs7308105 | HOXC4 | GWAS association (p=5.0e-08) | Large GWAS |
| rs139959245 | — | GWAS association (p=5.0e-08) | Large GWAS |
| rs3742909 | SMOC1 | GWAS association (p=5.0e-08) | Large GWAS |
| rs13182402 | ALDH7A1 | GWAS association (p=2.0e-09) | Small GWAS |
| rs9921222 | AXIN1 | Increased osteoporosis risk | Candidate gene study |
Associations aggregated from the GWAS Catalog and curated literature. Informational only — not medical advice.