WLS
Wnt ligand secretion mediator
Summary
Enables Wnt-protein binding activity and identical protein binding activity. Involved in positive regulation of cell communication and protein transport. Located in several cellular components, including Golgi apparatus; early endosome; and endoplasmic reticulum membrane. Implicated in Zaki syndrome. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants48 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs12740674 | 1:68,587,458 | C/T | regulatory region variant | — |
| rs773311381 | 1:68,591,929 | G/A | — | likely pathogenic |
| rs2100377758 | 1:68,591,943 | A/G | — | likely pathogenic |
| rs764940216 | 1:68,603,465 | T/C | — | uncertain significance |
| rs2524083742 | 1:68,603,478 | C/G | — | uncertain significance |
| rs367885134 | 1:68,603,483 | T/C | — | uncertain significance |
| rs142571662 | 1:68,603,512 | C/T | — | uncertain significance |
| rs2524083972 | 1:68,603,529 | A/G | — | uncertain significance |
| rs985347096 | 1:68,603,546 | T/C | — | pathogenic |
| rs2524084223 | 1:68,603,565 | C/A | — | uncertain significance |
| rs140465138 | 1:68,603,612 | G/A | — | uncertain significance |
| rs1056055466 | 1:68,606,895 | G/T | — | uncertain significance |
| rs778142595 | 1:68,610,260 | C/T | — | uncertain significance |
| rs150138976 | 1:68,610,316 | T/C | — | uncertain significance |
| rs200028453 | 1:68,611,616 | C/T | — | uncertain significance |
| rs2100452147 | 1:68,611,655 | T/C | — | pathogenic |
| rs1646747946 | 1:68,611,662 | A/C | — | uncertain significance |
| rs2524136519 | 1:68,615,882 | C/T | — | uncertain significance |
| rs2524136762 | 1:68,615,924 | A/G | — | uncertain significance |
| rs373703620 | 1:68,615,927 | T/C | — | uncertain significance |
| rs199608520 | 1:68,619,201 | T/G | — | uncertain significance |
| rs750375780 | 1:68,619,278 | G/A | — | uncertain significance |
| rs1170413503 | 1:68,619,285 | A/G | — | uncertain significance |
| rs566622107 | 1:68,619,301 | C/G | — | uncertain significance |
| rs553213704 | 1:68,620,789 | C/T | — | uncertain significance |
| rs2524156138 | 1:68,620,843 | G/A | — | uncertain significance |
| rs775625231 | 1:68,620,850 | G/A | — | uncertain significance |
| rs764309802 | 1:68,620,872 | A/T | — | uncertain significance |
| rs750231429 | 1:68,620,874 | G/A | — | uncertain significance |
| rs1411699742 | 1:68,620,894 | A/G | — | uncertain significance |
| rs930663487 | 1:68,620,953 | G/T | — | likely benign |
| rs777451767 | 1:68,624,871 | C/T | — | uncertain significance |
| rs3748705 | 1:68,624,878 | C/T | — | benign |
| rs762774039 | 1:68,624,880 | C/T | — | uncertain significance |
| rs767220868 | 1:68,624,907 | C/A | — | uncertain significance |
| rs1455578958 | 1:68,624,909 | A/G | — | uncertain significance |
| rs1367448 | 1:68,633,924 | G/A | intron variant | — |
| rs1430742 | 1:68,635,075 | T/C | intron variant | — |
| rs2566755 | 1:68,635,390 | T/C | intron variant | — |
| rs12407028 | 1:68,647,716 | T/A | — | — |
| rs1430740 | 1:68,657,510 | T/C | intron variant | — |
| rs750696001 | 1:68,659,726 | G/A | — | likely benign |
| rs541503463 | 1:68,659,763 | A/G | — | uncertain significance |
| rs150131585 | 1:68,659,790 | T/C | — | uncertain significance |
| rs553607184 | 1:68,659,856 | C/T | — | uncertain significance |
| rs57748040 | 1:68,660,893 | G/A | intron variant | — |
| rs760671910 | 1:68,697,879 | A/G | — | uncertain significance |
| rs746323384 | 1:68,697,958 | T/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.