rs3779381
▶GWAS Catalog Trait Associations (10)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (10)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
heel bone mineral density
Morris JA et al. “An atlas of genetic influences on osteoporosis in humans and mice.” Nature Genetics 51(2):258-266 (2019)
Allele A
OR 0.08
p 4.0e-143
N 426,824
Large GWAS
European
trunk bone mineral density
Qian 钱雨 Y et al. “Genome-wide Association Studies of over 30,000 Samples with Bone Mineral Density at Multiple Skeletal Sites and Its Clinical Relevance.” Genomics, Proteomics & Bioinformatics 23(5) (2025)
Allele G
OR 0.09
p 3.0e-22
N 31,986
Large GWAS
European
bone quantitative ultrasound measurement
Mullin BH et al. “Genome-wide association study meta-analysis for quantitative ultrasound parameters of bone identifies five novel loci for broadband ultrasound attenuation.” Human Molecular Genetics 26(14):2791-2802 (2017)
Allele G
OR 0.19
p 1.0e-21
N 16,627
Meta-analysisLarge GWAS
European
spine bone mineral density
Qian 钱雨 Y et al. “Genome-wide Association Studies of over 30,000 Samples with Bone Mineral Density at Multiple Skeletal Sites and Its Clinical Relevance.” Genomics, Proteomics & Bioinformatics 23(5) (2025)
Allele G
OR 0.09
p 9.0e-20
N 31,986
Large GWAS
European
Pei YF et al. “Joint study of two genome-wide association meta-analyses identified 20p12.1 and 20q13.33 for bone mineral density.” Bone 110:378-385 (2018)
Allele G
OR 0.08
p 1.0e-18
N 40,491
Large GWAS
multi-ancestry
adipose amount
Ahmed A et al. “MRI-Based Genetic Studies Reveal Specific Genetic Variants and Disease Risks Associated With Fat Distribution Across Anatomical Sites.” Journal of Obesity 2025:7792701 (2025)
Allele A
OR 0.07
p 5.0e-19
N 37,589
Large GWAS
European
femoral neck bone mineral density
Qian 钱雨 Y et al. “Genome-wide Association Studies of over 30,000 Samples with Bone Mineral Density at Multiple Skeletal Sites and Its Clinical Relevance.” Genomics, Proteomics & Bioinformatics 23(5) (2025)
Allele G
OR 0.08
p 2.0e-16
N 32,017
Large GWAS
European
Pei YF et al. “Joint study of two genome-wide association meta-analyses identified 20p12.1 and 20q13.33 for bone mineral density.” Bone 110:378-385 (2018)
Allele G
OR 0.06
p 1.0e-14
N 40,491
Large GWAS
multi-ancestry
osteoporosis
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele G
OR 0.12
p 5.0e-15
N 667,227
Large GWAS
multi-ancestry
Drugs affecting bone structure and mineralization use measurement
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele G
OR 0.10
p 5.0e-11
N 394,394
Large GWAS
multi-ancestry
Wu Y et al. “Genome-wide association study of medication-use and associated disease in the UK Biobank.” Nature Communications 10(1):1891 (2019)
Allele G
OR 0.11
p 5.0e-10
N 215,668
Major Consortium StudyLarge GWAS
European
pelvis bone mineral density
Qian 钱雨 Y et al. “Genome-wide Association Studies of over 30,000 Samples with Bone Mineral Density at Multiple Skeletal Sites and Its Clinical Relevance.” Genomics, Proteomics & Bioinformatics 23(5) (2025)
Allele G
OR 0.06
p 4.0e-10
N 31,873
Large GWAS
European
bone tissue density
Qian 钱雨 Y et al. “Genome-wide Association Studies of over 30,000 Samples with Bone Mineral Density at Multiple Skeletal Sites and Its Clinical Relevance.” Genomics, Proteomics & Bioinformatics 23(5) (2025)
Allele G
OR 0.17
p 2.0e-75
N 31,986
Large GWAS
European
▶Research that mentions this SNP (1)
▶Missense polymorphisms of the WNT16 gene are associated with bone mass, hip geometry and fracturesAssociationN=1,083García-Ibarbia C. et al.(2013)· Osteoporosis International
Missense polymorphisms of the WNT16 gene are associated with bone mass, hip geometry and fractures
AssociationN=1,083García-Ibarbia C. et al.(2013)· Osteoporosis International
Two missense polymorphisms of the WNT16 gene (rs2908004 and rs2707466) were associated with hip bone mineral density (BMD), femoral neck buckling ratio, and calcaneal ultrasound parameters in 1,083 postmenopausal women and elderly men. In individuals under 80 years old, rs2908004 was associated with decreased hip fracture risk (OR=0.50, p=0.03), confirming WNT16's role in bone mass regulation and osteoporotic fracture susceptibility.
Traits studied:Bone mineral densityCalcaneal ultrasound parametersFemoral neck geometryHip fracturesOsteoporosis
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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