rs11228240
▶GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
heel bone mineral density
Morris JA et al. “An atlas of genetic influences on osteoporosis in humans and mice.” Nature Genetics 51(2):258-266 (2019)
Allele C
OR 0.03
p 2.0e-54
N 426,824
Large GWAS
European
bone tissue density
Medina-Gomez C et al. “Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis.” Communications Biology 6(1):691 (2023)
Allele T
OR 0.10
p 4.0e-36
N 43,832
Large GWAS
European
Medina-Gomez C et al. “Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.” American Journal of Human Genetics 102(1):88-102 (2018)
Allele T
OR —
β 0.097
p 3.0e-8
N 10,062
Meta-analysisLarge GWAS
European, NR
osteoporosis
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele T
OR 0.14
p 2.0e-14
N 394,626
Large GWAS
European
Drugs affecting bone structure and mineralization use measurement
Wu Y et al. “Genome-wide association study of medication-use and associated disease in the UK Biobank.” Nature Communications 10(1):1891 (2019)
Allele T
OR 0.11
p 1.0e-9
N 215,668
Major Consortium StudyLarge GWAS
European
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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