rs11090045

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GWAS Catalog Trait Associations (8)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

mathematical ability

Lee JJ et al. “Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.” Nature Genetics 50(8):1112-1121 (2018)
Allele G
OR 0.03
p 1.0e-32
N 564,698
Large GWAS
European

neuroticism measurement

Luciano M et al. “Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism.” Nature Genetics 50(1):6-11 (2018)
Allele A
OR 8.72
p 3.0e-18
N 329,821
Large GWAS
European
Nagel M et al. “Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.” Nature Genetics 50(7):920-927 (2018)
Allele A
OR 8.71
p 3.0e-18
N 449,484
Meta-analysisLarge GWAS
European
Nagel M et al. “Item-level analyses reveal genetic heterogeneity in neuroticism.” Nature Communications 9(1):905 (2018)
Allele A
OR 7.56
p 4.0e-14
N 380,506
Large GWAS
European
Kim Y et al. “Genetic and neural bases of the neuroticism general factor.” Biological Psychology 184:108692 (2023)
Allele A
OR 0.01
p 4.0e-13
N 380,000
Large GWAS
Nagel M et al. “Genome-wide association study of the sensitivity to environmental stress and adversity neuroticism cluster.” Acta Psychiatrica Scandinavica 141(5):476-478 (2020)
Allele A
OR —
β 0.015
p 6.0e-9
N 351,827
Large GWAS
European

Anxiety

Nagel M et al. “Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.” Nature Genetics 50(7):920-927 (2018)
Allele A
OR 0.02
p 1.0e-11
N 348,219
Meta-analysisLarge GWAS
European

neurotic disorder

Cai N et al. “Minimal phenotyping yields genome-wide association signals of low specificity for major depression.” Nature Genetics 52(4):437-447 (2020)
Allele A
OR 0.01
p 1.0e-11
N 274,107
Large GWAS
European

feeling tense measurement

Nagel M et al. “Item-level analyses reveal genetic heterogeneity in neuroticism.” Nature Communications 9(1):905 (2018)
Allele A
OR 6.38
p 2.0e-10
N 371,318
Large GWAS
European

smoking cessation

Xu K et al. “Genome-wide association study of smoking trajectory and meta-analysis of smoking status in 842,000 individuals.” Nature Communications 11(1):5302 (2020)
Allele G
OR 1.03
p 1.0e-8
N 450,129
Meta-analysisLarge GWAS
European

feeling nervous measurement

Nagel M et al. “Item-level analyses reveal genetic heterogeneity in neuroticism.” Nature Communications 9(1):905 (2018)
Allele A
OR 5.55
p 3.0e-8
N 373,121
Large GWAS
European

alcohol consumption quality

Schoeler T et al. “Participation bias in the UK Biobank distorts genetic associations and downstream analyses.” Nature Human Behaviour 7(7):1216-1227 (2023)
Allele A
OR 0.16
p 4.0e-8
N 283,162
Major Consortium StudyLarge GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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