rs11119345
This is a intron variant variant in the TRAF3IP3 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
Orofacial cleft
Leslie EJ et al. “A multi-ethnic genome-wide association study identifies novel loci for non-syndromic cleft lip with or without cleft palate on 2p24.2, 17q23 and 19q13.” Human Molecular Genetics 25(13):2862-2872 (2016)
Allele G
OR 1.81
p 3.0e-13
N 1,096
Large GWAS
African unspecified
About TRAF3IP3
The gene encodes a protein that mediates cell growth by modulating the c-Jun N-terminal kinase signal transduction pathway. The encoded protein may also interact with a large multi-protein assembly containing the phosphatase 2A catalytic subunit. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
View all TRAF3IP3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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