rs11121542
This is a intron variant variant in the KIF1B gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
Abnormality of the skeletal system
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.02
p 1.0e-18
N 394,642
Large GWAS
European
monocyte percentage of leukocytes
Vuckovic D et al. “The Polygenic and Monogenic Basis of Blood Traits and Diseases.” Cell 182(5):1214-1231.e11 (2020)
Allele A
OR 0.03
p 1.0e-14
N 408,112
Large GWAS
European
grip strength measurement
Tikkanen E et al. “Biological Insights Into Muscular Strength: Genetic Findings in the UK Biobank.” Scientific Reports 8(1):6451 (2018)
Allele A
OR 0.00
p 3.0e-10
N 334,825
Major Consortium StudyLarge GWAS
European
About KIF1B
Enables plus-end-directed microtubule motor activity. Involved in apoptotic process involved in development and mitochondrion transport along microtubule. Is active in mitochondrion. Implicated in Charcot-Marie-Tooth disease type 2A1; hepatocellular carcinoma; multiple sclerosis; neuroblastoma; and ovary epithelial cancer. Biomarker of hepatocellular carcinoma. [provided by Alliance of Genome Resources, Jul 2025]
View all KIF1B variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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