KIF1B

kinesin family member 1B

Summary

Enables plus-end-directed microtubule motor activity. Involved in apoptotic process involved in development and mitochondrion transport along microtubule. Is active in mitochondrion. Implicated in Charcot-Marie-Tooth disease type 2A1; hepatocellular carcinoma; multiple sclerosis; neuroblastoma; and ovary epithelial cancer. Biomarker of hepatocellular carcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants2,505 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs149705989	1:10,270,756	T/C	—	likely benign
rs146663377	1:10,270,808	G/C	—	benign
rs867021284	1:10,270,870	C/T	—	uncertain significance
rs181820595	1:10,270,880	C/T	—	benign
rs528568887	1:10,270,889	G/A	—	likely benign
rs1646683353	1:10,270,919	G/A	—	uncertain significance
rs140240544	1:10,270,937	G/T	—	benign
rs1646683776	1:10,270,949	G/A	—	uncertain significance
rs12093553	1:10,272,989	T/C	intron variant	—
rs997482	1:10,273,179	C/T	intron variant	—
rs147613335	1:10,284,267	C/T	upstream gene variant	—
rs17396340	1:10,286,176	G/C	—	—
rs886044965	1:10,292,304	A/G	—	uncertain significance
rs529564378	1:10,292,319	G/A	—	uncertain significance
rs200491456	1:10,292,382	T/C	—	conflicting classifications of pathogenicity
rs2523352527	1:10,292,386	A/C	—	uncertain significance
rs1272900057	1:10,292,391	C/T	—	uncertain significance
rs1646993926	1:10,292,392	G/A	—	likely benign
rs2523352556	1:10,292,394	G/T	—	uncertain significance
rs1435615537	1:10,292,404	G/A	—	likely benign
rs758134092	1:10,292,406	A/T	—	uncertain significance
rs2523352615	1:10,292,409	T/C	—	uncertain significance
rs2523352634	1:10,292,417	C/A	—	likely benign
rs2523352650	1:10,292,420	G/T	—	uncertain significance
rs2523352656	1:10,292,422	A/G	—	likely benign
rs2523352669	1:10,292,425	G/A	—	likely benign
rs2523352682	1:10,292,428	C/T	—	likely benign
rs2523352691	1:10,292,432	A/T	—	uncertain significance
rs1409278786	1:10,292,433	A/G	—	uncertain significance
rs746087314	1:10,292,434	T/C	—	likely benign
rs2523352722	1:10,292,435	T/C	—	uncertain significance
rs2523352757	1:10,292,439	G/A	—	uncertain significance
rs538135467	1:10,292,445	C/T	—	conflicting classifications of pathogenicity
rs751386973	1:10,292,446	C/G	—	likely benign
rs769237267	1:10,292,447	A/G	—	uncertain significance
rs774652777	1:10,292,448	G/T	—	uncertain significance
rs1425290978	1:10,292,449	C/T	—	likely benign
rs762280202	1:10,292,451	A/G	—	uncertain significance
rs2523352898	1:10,292,455	A/G	—	likely benign
rs1646994662	1:10,292,457	C/G	—	uncertain significance
rs1427632250	1:10,292,458	C/T	—	likely benign
rs1371178343	1:10,292,460	A/G	—	uncertain significance
rs772548887	1:10,292,464	C/T	—	likely benign
rs2523352991	1:10,292,465	A/G	—	uncertain significance
rs142464329	1:10,292,467	C/T	—	likely benign
rs1646994908	1:10,292,468	A/C	—	uncertain significance
rs2523353026	1:10,292,470	T/G	—	uncertain significance
rs760368705	1:10,292,471	C/G	—	conflicting classifications of pathogenicity
rs2523353047	1:10,292,472	A/G	—	uncertain significance
rs2102129325	1:10,292,473	G/C	—	uncertain significance
rs2523353071	1:10,292,474	A/T	—	uncertain significance
rs890108015	1:10,292,477	C/G	—	uncertain significance
rs765851262	1:10,292,479	A/G	—	likely benign
rs1646995102	1:10,292,484	A/G	—	uncertain significance
rs1269940164	1:10,292,487	C/T	—	uncertain significance
rs1646995202	1:10,292,488	G/A	—	likely benign
rs2523353148	1:10,292,489	A/G	—	uncertain significance
rs2523353154	1:10,292,491	C/T	—	conflicting classifications of pathogenicity
rs368714043	1:10,292,502	T/A	—	likely benign
rs2523353202	1:10,292,511	C/T	—	likely benign
rs75006767	1:10,292,688	C/G	—	benign
rs561741258	1:10,297,886	G/A	—	—
rs4846204	1:10,308,958	C/A	—	—
rs2523453854	1:10,316,286	A/C	—	likely benign
rs1377538951	1:10,316,289	C/T	—	likely benign
rs2523453948	1:10,316,290	A/G	—	likely benign
rs936173191	1:10,316,292	T/C	—	likely benign
rs1647773753	1:10,316,294	T/G	—	likely benign
rs749389756	1:10,316,297	T/A	—	conflicting classifications of pathogenicity
rs1400237234	1:10,316,301	C/G	—	likely benign
rs1324984536	1:10,316,305	G/A	—	uncertain significance
rs779530504	1:10,316,307	A/G	—	uncertain significance
rs2102181683	1:10,316,315	C/T	—	likely benign
rs2523454099	1:10,316,317	C/G	—	uncertain significance
rs143000567	1:10,316,326	C/T	—	uncertain significance
rs2523454146	1:10,316,329	A/T	—	uncertain significance
rs761068179	1:10,316,330	G/A	—	likely benign
rs1647775746	1:10,316,333	A/C	—	uncertain significance
rs770626277	1:10,316,335	C/T	—	uncertain significance
rs1259401176	1:10,316,336	T/G	—	likely benign
rs975589148	1:10,316,342	G/A	—	likely benign
rs143654307	1:10,316,344	C/A	—	conflicting classifications of pathogenicity
rs2523454274	1:10,316,345	C/T	—	likely benign
rs759145971	1:10,316,347	T/A	—	uncertain significance
rs2523454300	1:10,316,348	C/T	—	likely benign
rs1252266328	1:10,316,349	A/G	—	uncertain significance
rs2523454332	1:10,316,351	C/G	—	uncertain significance
rs764651787	1:10,316,354	C/T	—	likely benign
rs1171875422	1:10,316,355	G/A	—	uncertain significance
rs752674254	1:10,316,357	C/T	—	conflicting classifications of pathogenicity
rs762856679	1:10,316,359	A/G	—	uncertain significance
rs1277944646	1:10,316,363	C/T	—	likely benign
rs2523454408	1:10,316,365	A/T	—	uncertain significance
rs530566864	1:10,316,366	C/T	—	likely benign
rs1051505837	1:10,316,378	C/T	—	likely benign
rs756935623	1:10,316,381	A/G	—	conflicting classifications of pathogenicity
rs7512451	1:10,316,382	G/A	—	uncertain significance
rs374304246	1:10,316,393	C/G	—	likely benign
rs1647779753	1:10,316,394	A/G	—	likely benign
rs17034616	1:10,316,627	C/G	—	benign

Showing 100 of 2,505 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.