Trait
SNPs associated with Hepatocellular carcinoma
26 genetic variants across 16 genes have been associated with Hepatocellular carcinoma in published research. Key genes include APOE, GRIK1, HFE.
Associated variants26 total
| rsid | Gene | Effect | Evidence |
|---|---|---|---|
| rs738408 | PNPLA3 | GWAS association (p=3.0e-93) | Meta-analysis |
| rs58542926 | TM6SF2 | GWAS association (p=3.0e-52) | Meta-analysis |
| rs144861591 | — | GWAS association (p=4.0e-20) | Meta-analysis |
| rs3179778 | HLA-DPA1 | GWAS association (p=1.0e-13) | Meta-analysis |
| rs4089 | MIR5705 | GWAS association (p=1.0e-13) | Meta-analysis |
| rs429358 | APOE | GWAS association (p=1.0e-13) | Meta-analysis |
| rs10069690 | TERT | GWAS association (p=7.0e-13) | Meta-analysis |
| rs12971396 | IFNL3 | GWAS association (p=3.0e-10) | Meta-analysis |
| rs2642442 | MTARC1 | GWAS association (p=4.0e-09) | Meta-analysis |
| rs7628416 | — | GWAS association (p=2.0e-08) | Meta-analysis |
| rs1042522 | TP53 | Increased hepatocellular carcinoma susceptibility | Meta-analysis |
| rs7574865 | STAT4 | Higher risk of hepatocellular carcinoma | Meta-analysis |
| rs9272105 | — | GWAS association (p=5.0e-22) | Large GWAS |
| rs2294915 | — | GWAS association (p=2.0e-19) | Large GWAS |
| rs9275319 | — | GWAS association (p=3.0e-17) | Large GWAS |
| rs2596542 | MICA | GWAS association (p=4.0e-13) | Large GWAS |
| rs58489806 | — | GWAS association (p=3.0e-12) | Large GWAS |
| rs455804 | GRIK1 | GWAS association (p=5.0e-10) | Large GWAS |
| rs73613962 | — | GWAS association (p=6.0e-10) | Large GWAS |
| rs8107030 | IFNL3 | GWAS association (p=8.0e-10) | Large GWAS |
| rs9275572 | — | GWAS association (p=6.0e-09) | Large GWAS |
| rs2242652 | TERT | GWAS association (p=6.0e-09) | Large GWAS |
| rs708113 | WNT3A | GWAS association (p=1.0e-08) | Large GWAS |
| rs17401966 | KIF1B | GWAS association (p=2.0e-18) | Small GWAS |
| rs2287780 | MTRR | Increased hepatocellular carcinoma risk in carriers | Preliminary work |
| rs1800562 | HFE | Increased hepatocellular carcinoma risk | Preliminary work |
Associations aggregated from the GWAS Catalog and curated literature. Informational only — not medical advice.