IFNL3
interferon lambda 3
Pharmacogene
Summary
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]
Known Variants35 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs4803217 | 19:39,734,220 | C/T | — | — |
| rs765409769 | 19:39,734,300 | C/T | — | uncertain significance |
| rs201104473 | 19:39,734,312 | C/T | — | uncertain significance |
| rs2513357101 | 19:39,734,321 | A/C | — | uncertain significance |
| rs1424506346 | 19:39,734,322 | G/A | — | uncertain significance |
| rs62120527 | 19:39,734,352 | C/T | — | benign |
| rs756085881 | 19:39,734,465 | T/G | — | uncertain significance |
| rs1274072452 | 19:39,734,469 | T/C | — | uncertain significance |
| rs2074927158 | 19:39,734,479 | C/G | — | uncertain significance |
| rs2513357563 | 19:39,734,483 | A/G | — | uncertain significance |
| rs139076671 | 19:39,734,490 | A/G | — | benign |
| rs759525840 | 19:39,734,505 | G/A | — | uncertain significance |
| rs1322841229 | 19:39,734,507 | C/T | — | uncertain significance |
| rs146276429 | 19:39,734,513 | C/T | — | uncertain significance |
| rs148543092 | 19:39,734,734 | T/C | — | benign |
| rs147679979 | 19:39,734,773 | C/G | — | benign |
| rs151331735 | 19:39,734,788 | G/A | — | uncertain significance |
| rs11881222 | 19:39,734,923 | A/G | downstream gene variant | drug response |
| rs2074933214 | 19:39,735,063 | C/G | — | uncertain significance |
| rs201418207 | 19:39,735,100 | C/T | — | benign |
| rs8103142 | 19:39,735,106 | T/C | missense variant | likely benign |
| rs375329061 | 19:39,735,475 | G/C | — | uncertain significance |
| rs753624869 | 19:39,735,511 | C/G | — | uncertain significance |
| rs549676428 | 19:39,735,528 | A/T | — | uncertain significance |
| rs148017150 | 19:39,735,549 | C/G | — | benign |
| rs2513360657 | 19:39,735,567 | G/A | — | uncertain significance |
| rs71356848 | 19:39,735,591 | A/G | — | uncertain significance |
| rs28416813 | 19:39,735,644 | C/G | downstream gene variant | — |
| rs4803219 | 19:39,735,919 | C/T | — | — |
| rs8107030 | 19:39,736,719 | A/G | upstream gene variant | — |
| rs370209610 | 19:39,737,576 | T/C | — | — |
| rs11882871 | 19:39,737,610 | A/G | regulatory region variant | — |
| rs369378118 | 19:39,737,760 | A/T | — | — |
| rs12971396 | 19:39,737,866 | C/A | missense variant | — |
| rs8099917 | 19:39,743,165 | T/G | regulatory region variant | drug response |
Gene information from NCBI Gene. Variant classifications from ClinVar.