rs11123857

This is a intron variant variant in the NPAS2 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

interleukin-1 receptor type 2 measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.05
p 7.0e-19
N 47,745
Large GWAS
European
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Research that mentions this SNP (1)

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Association of Tef polymorphism with depression in Parkinson disease
AssociationN=408Ping Hua et al.(2012)· Movement Disorders

This study examined the association between circadian gene polymorphisms and depression severity in 408 Parkinson's disease patients. The Tef rs738499 polymorphism was significantly associated with higher Hamilton Depression Rating Scale (HAMD) scores (P = 0.004), explaining 1.8% of variance in depression symptoms after adjusting for clinical variables. Cry1 rs2287161 and Cry2 rs10838524 showed no significant associations with depression in this PD cohort.

Traits studied:Depression in Parkinson's diseaseSleep disturbances
PubMedDOIMetascience Observatory

About NPAS2

The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain. [provided by RefSeq, Jul 2008]

View all NPAS2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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