rs111654000
This is a intron variant variant in the DENND4C gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
sleep apnea measurement
Cade BE et al. “Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program.” Genome Medicine 13(1):136 (2021)
Allele A
OR 11.94
p 3.0e-8
N 1,942
Large GWAS
African American or Afro-Caribbean
About DENND4C
Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in cellular response to insulin stimulus; protein localization to plasma membrane; and regulation of Rab protein signal transduction. Located in Golgi apparatus and cytosol. [provided by Alliance of Genome Resources, Jul 2025]
View all DENND4C variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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