rs11172113

This variant is located in the LRP1 gene.

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GWAS Catalog Trait Associations (27)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

migraine disorder

Hautakangas H et al. “Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles.” Nature Genetics 54(2):152-160 (2022)
Allele T
OR 1.11
p 1.0e-90
N 873,341
Large GWAS
European
Choquet H et al. “New and sex-specific migraine susceptibility loci identified from a multiethnic genome-wide meta-analysis.” Communications Biology 4(1):864 (2021)
Allele T
OR 0.90
p 1.0e-28
N 554,569
Meta-analysisLarge GWAS
multi-ancestry
Gormley P et al. “Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.” Nature Genetics 48(8):856-66 (2016)
Allele T
OR 1.11
p 6.0e-49
N 375,752
Meta-analysisLarge GWAS
European
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.09
p 8.0e-21
N 315,668
Major Consortium StudyLarge GWAS
European
Chasman DI et al. “Genome-wide association study reveals three susceptibility loci for common migraine in the general population.” Nature Genetics 43(7):695-8 (2011)
Allele T
OR 1.11
p 4.0e-9
N 23,230
Large GWAS
European

Headache

Meng W et al. “A Genome-Wide Association Study Finds Genetic Associations with Broadly-Defined Headache in UK Biobank (N=223,773).” Ebiomedicine 28:180-186 (2018)
Allele C
OR 0.02
p 5.0e-47
N 223,782
Major Consortium StudyLarge GWAS
European

spontaneous coronary artery dissection

Adlam D et al. “Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation.” Nature Genetics 55(6):964-972 (2023)
Allele T
OR 1.62
p 9.0e-31
N 11,209
Meta-analysisLarge GWAS
European
Turley TN et al. “Identification of Susceptibility Loci for Spontaneous Coronary Artery Dissection.” Jama Cardiology 5(8):929-938 (2020)
Allele T
OR 1.69
p 1.0e-13
N 1,961
Large GWAS
European

FEV/FVC ratio

Shrine N et al. “Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk.” Nature Genetics 55(3):410-422 (2023)
Allele T
OR 11.45
p 2.0e-30
N 588,452
Large GWAS
multi-ancestry
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele T
OR 0.02
p 3.0e-21
N 394,642
Large GWAS
European
Shrine N et al. “New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.” Nature Genetics 51(3):481-493 (2019)
Allele T
OR 0.02
p 7.0e-21
N 321,047
Large GWAS
European

aneurysm

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.09
p 6.0e-24
N 439,723
Major Consortium StudyLarge GWAS
European

aortic aneurysm

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.09
p 4.0e-20
N 621,215
Major Consortium StudyLarge GWAS
multi-ancestry
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele T
OR 0.13
p 3.0e-8
N 653,950
Large GWAS
multi-ancestry

appendicular lean mass

Pei YF et al. “The genetic architecture of appendicular lean mass characterized by association analysis in the UK Biobank study.” Communications Biology 3(1):608 (2020)
Allele T
OR 0.02
p 5.0e-17
N 450,243
Major Consortium StudyLarge GWAS
European

coronary atherosclerosis

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.04
p 4.0e-16
N 424,341
Major Consortium StudyLarge GWAS
European

migraine without aura, susceptibility to, 4

Gormley P et al. “Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.” Nature Genetics 48(8):856-66 (2016)
Allele T
OR 1.18
p 4.0e-16
N 147,970
Meta-analysisLarge GWAS
European
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Research that mentions this SNP (1)

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Using a Genetic Risk Score Approach to Predict Headache Response to Triptans in Migraine Without Aura
AssociationN=172Sarah Cargnin et al.(2019)· The Journal of Clinical Pharmacology

A genetic risk score combining risk alleles at TRPM8 rs6724624 and FGF6 rs1024905 was inversely associated with inconsistent response to triptans in 172 migraine without aura (MwoA) patients (OR 0.62, 95% CI 0.43-0.89, FDR q=0.045). Adding this 2-SNP genetic risk score to a triptan-adjusted model significantly improved discrimination accuracy from AUC 0.57 to 0.64 (P=0.037), suggesting potential utility for predicting poor triptan responders.

Traits studied:Migraine without auraTriptan response
PubMedDOIMetascience Observatory

About LRP1

This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]

View all LRP1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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