rs111789331

This is a downstream gene variant variant.

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GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Alzheimer disease, family history of Alzheimer’s disease

Willett JDS et al. “Identification of 16 novel Alzheimer's disease loci using multi-ancestry meta-analyses.” Alzheimer's & Dementia : the Journal of the Alzheimer's Association 21(2):e14592 (2025)

Allele A

OR —

p 2.0e-228

N 404,467

Large GWAS

multi-ancestry

Alzheimer disease

Allele A

OR —

p 2.0e-158

N 27,907

Large GWAS

European, African unspecified, Hispanic or Latin American, Asian unspecified, NR

Lewy body dementia

Mitsumori R et al. “A genome-wide association study identifies a novel East Asian-specific locus for dementia with Lewy bodies in Japanese subjects.” Molecular Medicine (cambridge, Mass.) 31(1):87 (2025)

Allele A

OR 2.59

p 7.0e-12

N 6,324

Large GWAS

East Asian

health study participation

Adams MJ et al. “Factors associated with sharing e-mail information and mental health survey participation in large population cohorts.” International Journal of Epidemiology 49(2):410-421 (2020)

Allele A

OR 0.01

p 1.0e-11

N 371,428

Large GWAS

European

HDL particle size

Davyson E et al. “Metabolomic Investigation of Major Depressive Disorder Identifies a Potentially Causal Association With Polyunsaturated Fatty Acids.” Biological Psychiatry 94(8):630-639 (2023)

Allele A

OR 0.04

p 3.0e-10

N 88,329

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

rs111789331

GWAS Catalog Trait Associations (5)

Alzheimer disease, family history of Alzheimer’s disease

Alzheimer disease

Lewy body dementia

health study participation

HDL particle size

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