rs11204752

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Thyroid stimulating hormone level

Rand SA et al. “Genome-wide association study and polygenic risk prediction of hypothyroidism.” Nature Genetics 57(12):3007-3015 (2025)

Allele C

OR 0.02

p 5.0e-18

N 482,873

Large GWAS

European

Williams AT et al. “Genome-wide association study of thyroid-stimulating hormone highlights new genes, pathways and associations with thyroid disease.” Nature Communications 14(1):6713 (2023)

Allele C

OR 0.02

p 2.0e-10

N 247,107

Large GWAS

multi-ancestry

neuroblastoma, cutaneous melanoma

Avitabile M et al. “Neural crest-derived tumor neuroblastoma and melanoma share 1p13.2 as susceptibility locus that shows a long-range interaction with the SLC16A1 gene.” Carcinogenesis 41(3):284-295 (2020)

Allele T

OR 1.10

p 2.0e-8

N 42,380

Large GWAS

European

hypothyroidism

White SL et al. “Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.” Nature Genetics 58(2):307-316 (2026)

Allele C

OR 0.03

p 1.0e-12

N 2,444,128

Large GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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