rs112107114

This is a intergenic variant variant.

GWAS Catalog Trait Associations (10)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

cholesteryl esters in medium VLDL measurement

Karjalainen MK et al. Genome-wide characterization of circulating metabolic biomarkers. Nature 628(8006):130-138 (2024)
Allele A
OR 0.11
p 1.0e-62
N 136,016
Large GWAS
multi-ancestry

triglycerides in very large HDL measurement

Karjalainen MK et al. Genome-wide characterization of circulating metabolic biomarkers. Nature 628(8006):130-138 (2024)
Allele A
OR 0.07
p 1.0e-29
N 136,016
Large GWAS
multi-ancestry

total cholesterol measurement, blood VLDL cholesterol amount, chylomicron amount

Karjalainen MK et al. Genome-wide characterization of circulating metabolic biomarkers. Nature 628(8006):130-138 (2024)
Allele A
OR 0.07
p 5.0e-26
N 136,016
Large GWAS
multi-ancestry

blood VLDL cholesterol amount, chylomicron amount

Karjalainen MK et al. Genome-wide characterization of circulating metabolic biomarkers. Nature 628(8006):130-138 (2024)
Allele A
OR 0.06
p 1.0e-19
N 136,016
Large GWAS
multi-ancestry

lipid measurement, blood VLDL cholesterol amount, chylomicron amount

Karjalainen MK et al. Genome-wide characterization of circulating metabolic biomarkers. Nature 628(8006):130-138 (2024)
Allele A
OR 0.06
p 2.0e-19
N 136,016
Large GWAS
multi-ancestry

aortic stenosis

Allele G
OR 0.05
p 3.0e-18
N 205,483
Large GWAS
European

triglyceride measurement, blood VLDL cholesterol amount, chylomicron amount

Karjalainen MK et al. Genome-wide characterization of circulating metabolic biomarkers. Nature 628(8006):130-138 (2024)
Allele A
OR 0.06
p 4.0e-18
N 136,016
Large GWAS
multi-ancestry

cholesteryl esters in large VLDL measurement

Karjalainen MK et al. Genome-wide characterization of circulating metabolic biomarkers. Nature 628(8006):130-138 (2024)
Allele A
OR 0.05
p 1.0e-16
N 136,016
Large GWAS
multi-ancestry

phospholipid level, blood VLDL cholesterol amount, chylomicron amount

Karjalainen MK et al. Genome-wide characterization of circulating metabolic biomarkers. Nature 628(8006):130-138 (2024)
Allele A
OR 0.05
p 1.0e-15
N 136,016
Large GWAS
multi-ancestry

triglycerides:total lipids ratio, high density lipoprotein cholesterol measurement

Karjalainen MK et al. Genome-wide characterization of circulating metabolic biomarkers. Nature 628(8006):130-138 (2024)
Allele A
OR 0.05
p 3.0e-15
N 136,016
Large GWAS
multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…