rs11228580

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

prostate cancer

Harris BHL et al. “New role of fat-free mass in cancer risk linked with genetic predisposition.” Scientific Reports 14(1):7270 (2024)
Allele C
OR 0.24
p 3.0e-31
N 151,994
Large GWAS
European
Janivara R et al. “Heterogeneous genetic architectures of prostate cancer susceptibility in sub-Saharan Africa.” Nature Genetics 56(10):2093-2103 (2024)
Allele C
OR 0.28
p 9.0e-12
N 7,472
Large GWAS
Sub-Saharan African

family history of prostate cancer

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.08
p 5.0e-13
N 400,487
Major Consortium StudyLarge GWAS
multi-ancestry

prostate carcinoma

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.23
p 5.0e-151
N 411,042
Major Consortium StudyLarge GWAS
European
Conti DV et al. “Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.” Nature Genetics 53(1):65-75 (2021)
Allele C
OR 1.27
p 5.0e-125
N 234,253
Meta-analysisLarge GWAS
multi-ancestry
Wang A et al. “Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants.” Nature Genetics 55(12):2065-2074 (2023)
Allele C
OR 1.28
p 2.0e-46
N 80,999
Large GWAS
African American or Afro-Caribbean
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Research that mentions this SNP (1)

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Comprehensive resequence analysis of a 123‐kb region of chromosome 11q13 associated with prostate cancer
AssociationN=84Charles C. Chung et al.(2012)· The Prostate

Comprehensive resequencing of a 122.9 kb region on chromosome 11q13.3 identified 644 polymorphic loci, including 166 novel variants not present in public databases. The study focused on fine-mapping prostate cancer susceptibility loci including rs10896438, rs12793759, rs10896449, and rs11228565, cataloguing 22-25 highly correlated surrogates (r² ≥ 0.8) for each locus and identifying functional regulatory elements. Indel polymorphisms comprised 13.4% of identified variants, with 58.5% novel to this study.

Traits studied:Prostate cancer
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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