rs113394178
This is a regulatory region variant variant in the ZNF358 gene.
▶GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
PR interval
Ntalla I et al. “Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction.” Nature Communications 11(1):2542 (2020)
Allele A
OR 0.46
p 2.0e-8
N 292,566
Large GWAS
multi-ancestry
electrocardiography
Verweij N et al. “The Genetic Makeup of the Electrocardiogram.” Cell Systems 11(3):229-238.e5 (2020)
Allele C
OR 0.03
p 1.0e-9
N 63,706
Major Consortium StudyLarge GWAS
European, NR
left ventricular structural measurement
Meyer HV et al. “Genetic and functional insights into the fractal structure of the heart.” Nature 584(7822):589-594 (2020)
Allele A
OR 0.07
p 7.0e-11
N 18,096
Large GWAS
European
QRS duration
Young WJ et al. “Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways.” Nature Communications 13(1):5144 (2022)
Allele A
OR 0.04
p 1.0e-18
N 212,199
Large GWAS
European
About ZNF358
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including embryonic forelimb morphogenesis; neural tube development; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
View all ZNF358 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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