rs1137522

This is a coding sequence variant variant in the JRK gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

schizophrenia

Bigdeli TB et al. “Genome-Wide Association Studies of Schizophrenia and Bipolar Disorder in a Diverse Cohort of US Veterans.” Schizophrenia Bulletin 47(2):517-529 (2021)

Allele C

OR 1.05

p 5.0e-9

N 177,741

Large GWAS

multi-ancestry

About JRK

This gene encodes a conserved protein that is similar to DNA-binding proteins, such as major centromere autoantigen B (CENPB). Inactivation of the related gene in mice resulted in epileptic seizures. Childhood Absence Epilepsy (CAE) has been mapped to the same chromosomal location (8q24.3) as this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

View all JRK variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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